对氯乙基氯苯的合成  

Synthesis of 1-Chloro-4-(2-Chloroethyl) Benzene

作　　者：张卫红[1] 吴卫忠[1] 

机构地区：[1]江苏工业学院化工系,常州213016

出　　处：《化工进展》2005年第12期1394-1395,1400,共3页Chemical Industry and Engineering Progress

摘　　要：以氯苯和氯乙酰氯为起始原料,经傅克酰基化和WolffKishner黄鸣龙两步反应合成对氯乙基氯苯。通过正交实验考察了原料配比、反应时间等因素与对氯乙酰基氯苯和对氯乙基氯苯收率的关系。结果表明:氯乙酰氯、无水AlCl3与氯苯的配比在1∶1.2∶4(物质的量比)时,反应时间2h,对氯乙酰基氯苯的收率可达84%。在第二步反应中,在120℃下对氯乙酰基氯苯与85%水合肼的投料比为1∶7(物质的量比)时,反应2h,对氯乙基氯苯的收率达到90.3%。Using chlorobertzene and chloroacetyl chloride as raw materials, 1-chloro-4-（2-chloroethyl） benzene was prepared via Friedel-Crafts acylation and Wolff-Kishner- Huangminglong reaction. By orthogonal design, it was studied respectively that effect on the yield of 4-chloro-benzeneacetyl chloride and 1-chloro-4-（2-chloroethyl）benzene, including mixture ratio, reaction time and so on. The yield of 4-chloro-benzeneacetyl chloride can reach 84% at 120 ℃ when the molar ratio of chloroacetyl chloride , anhydrous aluminium chloride and chlorobenzene was 1 ： 1.2 ： 4 and reaction time was 2 h. 4-chloro-benzeneacetyl chloride reacted with diamide which molar ratio was 1 ： 7 in solvent for 2 h to give 90. 3% of 1-chloro-4-（2-chloroethyl）benzene.

关 键 词：对氯乙基氯苯 对氯乙酰基氯苯 唑茵腈 杀菌剂 

分 类 号：TQ455.4[化学工程—农药化工]