禽流感危机  

The Threat of Avian Influenza A Viruses

作　　者：王凯[1] 彭晓霞[2] 于琦[1] 陈凯[1] 孔德军[1] 曾婉利[1] 张萍[1] 齐银[1] 迟宓宓[2] 郭爱民[2] 王嵬 

机构地区：[1]中国科学院研究生院 [2]首都医科大学公共卫生与家庭医学学院流行病学与卫生统计学系

出　　处：《首都医科大学学报》2005年第6期695-698,共4页Journal of Capital Medical University

摘　　要：禽流感病毒的血凝素(hemagglutinin,HA)和神经氨酸酶(neuraminidase,NA)均易发生抗原漂移和抗原转换,可突变出快速感染人类并致病的亚型,特别是H5N1型具有从感染其他动物种属的流感病毒中获得基因并迅速转变的能力,威胁人类健康。世界候鸟的迁徙更使全球面临禽流感危急,本文就禽流感的病毒特征、感染机制及其防治和鸟类迁徙对禽流感传播的影响进行综述。Hemagglutinin （HA） and Neuraminidase （NA） of influenza viruses are easy to have antigenic drift and antigenic shift, and new pathogenic subtype which is able to infect humans can be formed by such viral mutations. Genetic reassembly which always happens in HSN1 subtype accderates the threat of avian influenza A viruses to human being. In addition, bird migration contributes to the global spread of emerging infectious disease. Therefore, we review current knowledge regarding the harm, pathological properties, pathogenicity of avian influenza viruses and discuss the influence of bird migration to the global spread of the viruses.

关 键 词：禽流感病毒 危机 抗原漂移 感染人类 神经氨酸酶 动物种属 人类健康 病毒特征 感染机制 血凝素 

分 类 号：R511.7[医药卫生—内科学] R535[医药卫生—临床医学]