乙肝大三阳患者肝细胞损伤与6项免疫指标相关性探讨  

Study of the relationship between hepatic cell injury and serum IgA,IgG,IgM,C_3,C_4,CRP of patients with chronic hepatitis B

作　　者：林勇[1] 李超强[1] 李华[1] 何永明[1] 郭主声[1] 陈日寿[1] 

机构地区：[1]中山大学东华医院检验科,广东东莞523110

出　　处：《国外医学（临床生物化学与检验学分册）》2005年第12期887-888,共2页Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine

摘　　要：目的探讨乙型肝炎大三阳患者肝细胞损伤与血清IgM、IgG、IgA、C3、C4及C反应蛋白(CRP)变化的关系。方法选择乙肝大三阳患者80例,根据丙氨酸氨基转移酶(ALT)值(ALT>200IU/L和<40IU/L)分为甲、乙两组,各40例,采用速率散射比浊法测定血清IgM、IgG、IgA、C3、C4及CRP。结果甲组血清IgA、IgG、CRP均高于乙组,两组差异具有统计学意义(P<0.05);血清IgM、C3、C4两组差异无统计学意义(P>0.05)。结论血清IgA、IgG、CRP有助于评估肝细胞损伤程度。Objective To study the relationship between hepatic cell injury and serum IgM, IgG,IgA,C3 ,C4 and CRP of patients with chronic hepatitis B. Methods Eighty cases of chronic hepatitis B were devided into two groups. The group 1 had 40 patients with ALT levels higher than 200 IU/ L and another 40 cases with ALT below 40 IU/L（group 2）. All of them were examined serum IgM, IgG,IgA,C3 ,C4 and CRP by the method of velocity scatter colorimetry. Results The levels of serum IgA,IgG,CRP of the group 1 were higher than those of group 2 （P〈0.05）, but the levels of serum IgM,C3 ,C4 were same. Conclusion Serum IgA,IgG,CRP can help to evaluate hepatic cell injury.

关 键 词：肝炎 乙型 免疫球蛋白类 补体 C反应蛋白 

分 类 号：R512.62[医药卫生—内科学]