左归饮加减对冠心病病人血浆内皮素、一氧化氮及红细胞变形性的影响  

Effects of modified Zuoguiyin on serum endothelin,nitricoxide and erythrocyte deformability in coronary heart disease

作　　者：李德伟[1] 李凤兰 沈霞[1] 李艳萍 田春时[4] 赵锦程[4] 

机构地区：[1]佳木斯市中心医院,黑龙江佳木斯154002 [2]鹤岗市药品检验所,黑龙江鹤岗154100 [3]哈尔滨武警支队卫生队,黑龙江哈尔滨151000 [4]佳木斯大学药理教研室,黑龙江佳木斯154007

出　　处：《黑龙江医药科学》2005年第6期9-10,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:本实验观察冠心病(CAD)病人使用左归饮加减治疗前后血浆内皮素(ET)、一氧化氮(NO)水平及红细胞变形性(ED)。方法:检测39例CAD病人治疗前后血浆ET、NO水平及ED。结果:冠心病病人血浆ET水平升高(P<0.01)、NO水平降低(P<0.01),红细胞滤过指数(IF)升高(P<0.01)。治疗后血浆ET水平下降(P<0.01),NO水平明显升高(P<0.01),红细胞IF降低(P<0.01)。对照组治疗前后各项指标均无明显变化。结论:左归饮可改善CAD病人血管内皮细胞功能,改善CAD病人血浆ET和NO水平,提高红细胞变形性,对CAD心绞痛具有一定的治疗价值。Objective： In order to study the effects of modified Zuoguiyin（ZGY） on serum endothelin （ET）, nitricoxide （NO） and erythrocyte deformability （ED） in coronary heart disease（CHD）. Methods： The serum ET, NO concent and erythrocyte filtration（IF） were measured in the patients with CHD before and after treatment by using modified Zuoguiyin. Results： The serum NO concent in the patients with CHD was much lower than that of the control（ P 〈 0.01 ）, the serum ET concent and erythrocyte IF were much higher than those of control（ P 〈 0.01 ）. After treatment with ZGY the serum NO concent in the patients with CHD was significantly higher than that of the group before treatment（ P 〈 0. 01 ）, the serum ET concent and erythrocyte IF were much lower, as compared with the group before treatment （ P 〈 0.01 ）. Conclusion： ZGY can protect the vascular endothel cells and enchance ED.

关 键 词：冠心病 内皮素 一氧化氮 红细胞 变形性 

分 类 号：R541.4[医药卫生—心血管疾病]