健心合剂对离体大鼠心脏冠脉流量及小鼠耳廓微循环的影响  

Effects of Jianxin mixture on coronary blood flow of rat isolated heart and microcirculation of mouse auricle

作　　者：张明远[1] 赵玉珍[1] 刘蕾[1] 付正宗[1] 王丽敏[1] 杨丽[1] 王淑香[1] 谭宏[1] 

机构地区：[1]佳木斯大学基础医学院药理教研室,黑龙江佳木斯154007

出　　处：《黑龙江医药科学》2005年第6期28-29,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:观察健心合剂对离体大鼠心脏冠脉流量及小鼠耳廓微循环的影响。方法:采用L angendorf法对大鼠离体心脏进行恒温恒压冠脉灌流,测定给药前、后冠脉流量及心肌收缩幅度、心率等变化,观察比较药物对冠脉血管的扩张作用及对心肌收缩幅度,心率的影响,以小鼠耳廓微循环的变化直接观测用药前后微循环的改变情况。结果:健心合剂能显著地增加大鼠心脏冠脉流量及心肌收缩幅度,减慢心率。使小鼠耳廓细动脉、细静脉的口径增大,毛细血管开放量增加。结论:健心合剂能增加冠脉流量,减慢心率,使心肌收缩幅度增加,改善微循环。Objective.To observe the effects of Jianxin mixture on the coronary blood flow of the rat isolated hearts and microcirculation of the mouse auricle. Methods.Langendorf was applied to the isolated heart perfusion to determine the coronary blood flow under constant temperature and pressure. The coronary blood flow, heart rate ,contractility and the microcirculation of the mouse auricle were observed before and after the application of the drug. Results. The drug significantly increased the coronary blood flow and contractility of the isolated heart, and the heart rate was decreased. The small arteries and veins were dilated and blood capillary was largely opened. Conclusion. Jianxin mixture can improve the microcirculation by increasing the coronary flood flow,heart contractility and decreasing the heart rate.

关 键 词：健心合剂 冠脉流量 微循环 

分 类 号：R285.5[医药卫生—中药学]