慢性肾功能衰竭患者血清瘦素与中医证型关系的研究  

Study on Relation between Serum Leptin and TCM Syndrome Types in the Patient of Chronic Renal Failure

作　　者：张文青 刘旭生 黄春林 邹川[2] 

机构地区：[1]广州中医药大学第二附属医院急诊科 [2]广州中医药大学2002级

出　　处：《中医杂志》2005年第12期928-930,共3页Journal of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助课题(102017)

摘　　要：目的:探讨慢性肾功能衰竭(CRF)患者血清瘦素浓度对营养状况的影响以及与 CRF 中医证型的关系。方法:CRF 组110例按中医辨证分成5个证型亚组,并设正常对照组30例。采用酶联免疫法测定血清瘦素浓度,并测量身高、体重,计算体质指数(BMI);CRF 组同时测定血清白蛋白、血清前白蛋白、转铁蛋白、血清肌酐、尿素氮、C 反应蛋白、血胰岛素,并计算营养风险指数(NRI)。结果:CRF 组血清瘦素水平高于正常对照组,CRF 组中脾肾气(阳)虚证两亚组血清瘦素水平、营养客观指标水平与其他3个亚组比较,差异均有显著性。结论:高瘦素血症可能是导致 CRF 患者营养不良的原因之一,脾肾气(阳)虚证血清瘦素水平明显高于非脾肾气(阳)虚证,推测血清瘦素可能是 CRF 脾肾气(阳)虚证的部分物质基础。Objective：To explore effect of serum leptin level on nutriture in the patient of chronic renal failure （CRF） and the relation with TCM syndrome types of CRF. Methods： 110 cases in CRF group were divided into 5 subtypes and 30 normal persons were used as control group. Serum leptin level, body height, body weight, and body mass index （BMI） were determined in both groups; and serum albumin ,serum pre-albumin ,transferin ,serum creatinine ,urea nitrogen ,C-reaction protein ,blood insulin, and nutrition risk index （NRI） were detected in CRF group. Results：Serum leptin level in CRF group was higher than that in the control group,and leptin level and nutritional index level in both the subtype groups of Qi- and Yang-deficiency of spleen and kidney were significantly different with those in other 3 subtype groups. Conclusion：High blood leptin is possibly one of the reasons inducing malnutriture of CRF patient,and serum leptin is possibly a partial basis of substances of Qi- and Yang-deficiency syndrome of CRF.

关 键 词：肾功能衰竭 慢性 诊断 辨证分型 血清瘦素 

分 类 号：R277.5[医药卫生—中医学]