心脏病医院真菌感染分析  

Analysis on fungal infection in Cardiac Hospitals

作　　者：崔敏[1] 张真路[1] 

机构地区：[1]武汉亚洲心脏病医院检验中心,武汉430022

出　　处：《医学与社会》2005年第12期24-25,共2页Medicine and Society

摘　　要：目的了解医院真菌感染的状况、病原菌分布、危险因素及耐药情况。方法对184例医院真菌感染患者进行了分析。结果医院真菌感染以白色假丝酵母菌64.1%、热带假丝酵母菌13.0%、光滑假丝酵母菌10.3%为主;CCU、ICU、术后病房呼吸系统感染率较高,感染率分别为30.4%、27.7%、25.5%,其中冠心病患者感染率40.2%最高;危险因素为广谱抗生素广泛运用、留置导尿管、静脉插管、气管插管及切开、手术治疗、住院时间长等;真菌感染对两性霉素、制霉菌素、氟康唑和5-氟胞嘧啶的敏感性较高,对酮康唑的耐药性较高。结论采用有效的防范措施,重视消除诱发因素,合理运用抗生素,早期诊断和治疗刻不容缓。Objict To eraluate the status and risk factors of fungal infections, and investigate the distribution and resistance of fungi in a cardiac hospital. Methods Analyzed 187 cases of fungal infections. Results The main pathogens of fungial infection were Candida albicans （64.1%）, Candida tropicalis （13.0%） and Candida glabrata （10.3%）. Those isolates mainly cause respiratory tract infections. The incidence of Fungi were 30.4% in CCU, 27.7% in ICU and 25.5% in the aftereatment ward, respectively. The major risk factors were： abuse of broadspectrum antibiotics, use of catheters and intubates, tracheotomy and trachea cannula, operation and long time in hospital, etc. Most isolates were susceptible to Amphotericin-B, Nystain, Fluconazole and 5-Flurocytosine, while resistant to Ketoconazole. Conclusions It is urgently for us to take effective measures to prevent fungal infections including reducing the risk factors and using antimicrobial agents rationally so as to diagnose and treat patients earlier.

关 键 词：心脏病医院 真菌感染 危险因素 抗真菌药物 

分 类 号：R184[医药卫生—流行病学]