卷烟烟气的毒理学指标与其重要有害成分之间的相关性  

Correlation between Toxicological Indexes and Main Harmful Components in Cigarette Smoke

作　　者：夭建华[1] 陈章玉[1] 吴平艳 王保兴[1] 方力[1] 

机构地区：[1]云南烟草科学研究院

出　　处：《烟草科技》2005年第12期17-20,共4页Tobacco Science & Technology

基　　金：云南省烟草公司资助项目(98B211-3)"卷烟烟气安全性评价的生物学方法研究及国内外名优卷烟烟气安全性比较研究"的内容之一

摘　　要：对22个牌号卷烟烟气的5项毒理学指标(MR值、SCE率、微核率、细胞死亡率和被动吸烟小鼠死亡率)和5项化学指标(焦油、烟碱、CO、TSNA和BaP)进行了相关分析和多元线性回归分析。结果表明:卷烟烟气生物效应与烟气中重要有害化学成分之间存在一定的相关性,其中TSNA是影响MR值、SCE率和细胞死亡率最重要的因素(P<0.01),而微核率和被动吸烟小鼠急性死亡率与焦油、烟碱、CO、TSNA、BaP均无相关性(P>0.05)。因此,大幅度降低卷烟烟气中的TSNA将有可能大大减少吸烟对健康的危害。The correlation analysis and multivariate linear regression analysis of five toxicological indexes （MR value, SCE frequency, micronucleus frequency, cell death rate and death rate of mouse by secondhand smoke exposure） and five main chemical indexes of cigarette smoke （tar, nicotine, CO, TSNAs and BaP） of cigarette smoke of 22 brands were carried out. The results showed that there existed some correlations between the toxicological indexes and harmful chemical components in cigarette smoke, in which TSNA was the most important factor influencing MR value, SCE frequency and cell death rate （ P 〈 0.01 ）, while the micronucleus frequency or death rate of mouse by secondhand smoke exposure was not correlated to tar, nicotine, CO, TSNAs and BaP （P 〉 0.05）. Therefore, substantial TSNAs reductions in cigarette smoke would probably reduce the hazards of smoking to health.

关 键 词：卷烟 有害成分 毒理学指标 相关性 

分 类 号：TS416[农业科学—烟草工业]