复方增效氯硝柳胺悬浮剂的研究 Ⅰ 复方悬浮剂的研制及特性分析  

Development of a novel synergism compound suspension concentrate Of niclosamide and chlorphoxim I . Formula and its characteristics

作　　者：戴建荣[1] 朱荫昌[1] 梁幼生[1] 李洪军[1] 龚明涛[2] 张均寿[2] 管晓虹[3] 

机构地区：[1]江苏省血吸虫病防治研究所 [2]中国药科大学 [3]南京医科大学

出　　处：《中国血吸虫病防治杂志》2005年第6期413-416,共4页Chinese Journal of Schistosomiasis Control

基　　金：国家高技术研究发展计划(863计划)(ID:2004AA2Z3540)江苏省卫生厅重大科研项目(ID:H200219)

摘　　要：目的研制复方增效氯硝柳胺悬浮剂,并分析其性能。方法将氯硝柳胺和氯辛硫磷与润湿剂、分散助悬剂和黏度调节剂等助剂混合,经球磨机研磨,制成复方增效氯硝柳胺悬浮剂。并对该制剂的黏度、粒径等进行分析,根据测定的氯硝柳胺和氯辛硫磷最大吸收峰波长,用高效液相法测定制剂中氯硝柳胺和氯辛硫磷的含量,并进行水溶液悬浮稳定性测定。结果复方增效氯硝柳胺悬浮剂是一种灰白色流动性黏稠液体,进入水体极易分散,可与水以任意比例混合。pH8．65,黏度137 mpa·s,药物颗粒粒径0．138-19．953μm,其中95．6％粒径<10 μm,82．24％粒径<5μm。氯硝柳胺的紫外吸收有3个峰值,分别为210、234 nm和332 nm,氯辛硫磷的吸收峰为269 nm。高效液相法测得复方增效剂氯硝柳胺含量为20．64％(W／W),氯辛硫磷含量为5．26％(W/W)。复方水溶液悬浮性2 h内中段氯硝柳胺含量均>100％,4 h仍为89．14％。结论新研制的复方增效氯硝柳胺悬浮剂是一种性能稳定,符合质量标准的制剂。Objective To develop a novel synergism compound suspension concentrate of niclosamide and chlorphoxim （Co-SCN） and sdudy its characteristics. Methods Niclosamide and chlorphoxim were milled by a ball mill and mixed with different amounts of wetting agent, dispersant agent, thickener, and water etc. , to develop Co-SCN, and the pH value, thickener, grain size were evaluated. The ultraviolet absorption spectrum of niclosamide and chlorphoxim were measured. The content of niclosamide and chlorphoxim in the solution were assayed by HPLC. Results Co-SCN was a gray thickener fluidity liquid. It was very easy to disperse and could be mixed with water in any proportion. Its pH was 8.65 and thickener was 137 mpa ·s. The grain sizes （diameter） were from 0. 138-19. 953 μm. Of them more than 95.6% was smaller than 10 μm and more than 82.24% was smaller than 5 μm. There were three peaks of ultraviolet absorption spectrum for niclosamide： 210, 234 nm and 334 nm respectively. One peak of chlorphoxim was at 269 nm. The novel formulation contained 20. 64% niclosamide and 5.26% chlorphoxim. The suspension stability of Co-SCN was 100% for 2 hours and 89.14G for 4 hours, and otherwise WPN in water was speedy sediment. Conclusion The novel synergism compound suspension concentrate of niclosamide and chlorphoxim is a stable quality and standard formulation.

关 键 词：氯硝柳胺 氯辛硫磷 悬浮剂 

分 类 号：TQ453.21[化学工程—农药化工] R383.24[医药卫生—医学寄生虫学]