乳猪股骨头骨骺早期缺血与恢复的增强磁共振成像  

Manifestation hyperabduction induced early reversible ischemia of the capital femoral epiphysis and its reversal in piglets on Gadolinium enhanced MRI

作　　者：李小明[1] 邵景范[2] 王仁法[1] 李勇刚[1] 唐立华[3] 徐安辉[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院放射科,武汉430030 [2]华中科技大学同济医学院附属同济医院小儿外科,武汉430030 [3]同济医学院组织胚胎学教研室

出　　处：《中华小儿外科杂志》2005年第1期46-48,共3页Chinese Journal of Pediatric Surgery

摘　　要：目的　确定Gadolinium(GD)增强磁共振成像 (magneticresonanceimaging ,MRI)能够检出早期股骨头骨骺缺血及恢复的变化。方法　 2 0例 2～ 3周龄乳猪 ,分为正常对照组 10例 ,缺血模型组10例。缺血模型组 10例 ,将双侧髋关节固定成为极度屈髋屈膝外展位 ,在持续固定 3～ 6h内对 10例乳猪的 2 0个股骨头进行动态GD增强MRI扫描 ,后解除固定自由行走 ,1d和 /或 7d后再次进行MRI扫描。观察此过程中股骨头增强MRI的表现特征 ,并与组织学发现相对照。结果　在GD增强MRI,可见 14个股骨头的骨骺软骨表现为不强化或弱强化的局部缺血征象 ,自由行走 1d后 10个股骨头完全恢复正常血供 ,7d后剩余 4个也完全恢复正常血供。结论　增强MRI能够检出因极度髋关节屈曲外展所致的乳猪股骨头骨骺早期缺血及恢复的变化。Objective To demonstrate whether Gadolinium-enhanced MRI can detect early reversible ischemia of the capital femoral epiphysis caused by hip hyperabduction in piglets. Methods Ten 2- to 3-week-old piglets were placed in maximal bilateral hip abduction bilaterally. Between 3 and 8 hours of consistent hyperabduction, dynamic gadolinium-enhanced MRI was performed in 20 femoral heads of 10 piglets. After MRI study, the piglets were allowed to ambulate freely for 1 or 7 days and re-imaged. Enhanced-MRI characteristics of epiphyseal and physeal cartilage and the secondary center of ossification were evaluated. And comparison between MRI appearances and histological findings was made. Results On Gadolinium-enhanced MRI, decreased or absent enhancement was seen in 14 cartilaginous epiphyses of all 20 femoral heads. Reperfusion was completed in 10 of 14 femoral heads after one day of ambulation and in the rest 4 after 7 days of ambulation. Conclusions Gadolinium-enhanced MRI can identify early ischemia and its reversal of the capital femoral epiphysis induced by hip hyperabdudion.

关 键 词：磁共振成像 软骨 骨骺 

分 类 号：R445.2[医药卫生—影像医学与核医学]