饮茶与胆道癌胆石症关系的全人群病例对照研究  

Tea consumption and risk of biliary tract cancers and gallstone disease: a population-based case-control study in Shanghai,China

作　　者：张学宏[1] 高玉堂[1] Asif Rashid 邓杰[1] 刘恩菊[1] 邬恺[1] 孙璐[1] 程家蓉[1] Gloria Gridley Ann W Hsing 

机构地区：[1]上海市肿瘤研究所,200032 [2]美国M.D.Anderson癌症中心 [3]美国国立癌症研究所

出　　处：《中华肿瘤杂志》2005年第11期667-671,共5页Chinese Journal of Oncology

摘　　要：目的探讨饮茶与胆道癌和胆石症的关系.方法采用全人群病例对照研究.研究对象为上海市区新发胆道癌患者627例,包括胆囊癌368例,肝外胆管癌191例和壶腹癌68例;按年龄(每5岁1组)频数配对的对照人群959人;同时收集胆石症患者1037例.采用非条件Logistic回归模型,分析饮茶与胆道癌、胆石症的关系. 结果与不饮茶者比较,女性胆囊癌、肝外胆管癌和胆石症组中现仍饮茶者的调整OR分别为0.57(95%CI: 0.34～0.96)、0.53(95%CI: 0.27～1.03)和0.71(95%CI: 0.51～0.99),肝外胆管癌OR值随饮茶年龄的提前及饮茶年限的增加而降低,趋势检验达到显著性水平.男性胆囊癌、肝外胆管癌和胆石症组OR均＜1,但尚无统计学意义.结论饮茶对女性胆囊癌、肝外胆管癌可能具有保护作用,这一保护作用不依赖于胆石症而具有独立性.Objective To investigate the relationship between tea consumption, biliary tract cancers and gallstone disease. Methods A population-based case-control study was conducted in urban Shanghai from 1 June 1997 to 31 May 2001 involving interviews with 627 new cases of biliary tract cancers （ including 368 cases of gallbladder cancer, 191 cases of extrahepatic bile duct cancer and 68 cases of cancer of the ampulla of Vater） aged 35 to 74 years and 959 population controls frequency-matched to cases by gender and age in five-year group. 1037 patients of gallstone disease were selected from the same hospital. All subjects were interviewed in person by trained interviewers by use of a structured questionnaire. Unconditional logistic regression analysis was used to calculate adjusted odds ratio （OR） and 95% confidence interval （CI）, Results Compared with tea non-drinkers, current tea consumption was inversely associated with risk of gallbladder cancer, extrahepatic bile duct cancer and gallstone disease among females with OR of 0.57 （95% CI： 0. 34-0.96）, 0.53 （95% CI： 0. 27-1.03） and 0.71 （95% CI： 0. 51-0.99）, respectively. OR declined with younger age at initiation of tea drinking and with longer duration of tea consumption（P for trend 〈 0.05）. Among males, the corresponding OR were mostly below one, although not statistically significant. Conclusion Tea consumption may decrease the risk of cancers of the gallbladder and extrahepatic bile duct among females. The protective effect appeares to be independent of gallstone disease.

关 键 词：胆道肿瘤 胆石症 饮茶 病例对照研究 

分 类 号：R735.8[医药卫生—肿瘤]