系统性红斑狼疮血清干扰素诱导蛋白10的检测及其意义  

Sera level of interferon-induced protein 10 and its clinical significance in patients with systemic lupus erythematosus

作　　者：江明[1] 薛梅[1] 张金华[1] 徐素平[1] 

机构地区：[1]南京医科大学附属淮安第一医院,223300

出　　处：《中国麻风皮肤病杂志》2005年第12期946-947,共2页China Journal of Leprosy and Skin Diseases

摘　　要：目的:检测系统性红斑狼疮(SLE)患者血清干扰素诱导蛋白10(IP-10)水平,并探讨其临床意义。方法:采用ELISA法检测58例SLE患者及40名正常对照者血清IP-10,比较分析其与SLE病情活动指数(SLEDAI)、肾损害、抗dsDNA、补体C3和白细胞计数的相关性。结果:SLE患者血清IP-10水平明显高于正常对照组(P<0.01),并且活动期高于静止期(P<0.01),肾损组高于无肾损组。血清IP-10水平与SLEDAI(P<0.01)、抗dsDNA抗体滴度对数值呈正相关(P<0.05),与C3(P<0.01)、白细胞计数(P<0.05)呈负相关。结论:检测血清IP-10水平有可能作为狼疮活动的敏感指标之一。Objective： To measure the sera level of interferon - induced protein 10 （IP- 10） in patients with systemic lupus erythematosus （SLE） and to explore its clinical significance. Methods： ELISA was used to evaluate IP- 10 level of sera in 58 patients with SLE and 40 normal controls. Results： The level of sera IP- 10 in SLE patients was higher than that in normal control group. In addition, sera IP- 10 level in active SLE was higher than that in quiescent SLE and the IP- 10 level of sera was significantly higher in patients with renal involvement than those without renal diseases. The level of sera IP - 10 in SLE patients showed significant positive correlations with SLEDAI score and logarithm value of sera anti - dsDNA antibody titer, and negative correlation with sera C3 level and white blood cell counts. Conclusion： The results indicate that the IP- 10 level of sera might be a sensitive index to the SLE activity.

关 键 词：系统性红斑狼疮 干扰素诱导蛋白10 

分 类 号：R593.24[医药卫生—内科学]