2型糖尿病患者血管病变及血糖变化与基底膜蛋白的关系  

Relationship of vessel lesion and glucose change with laminin in type 2 diabetes patients

作　　者：徐滨华[1] 赵环宇[1] 吴东红[1] 刘岳鸿[1] 

机构地区：[1]哈尔滨市第一医院内分泌科,黑龙江省哈尔滨市150010

出　　处：《中国临床康复》2005年第43期47-49,共3页Chinese Journal of Clinical Rehabilitation

基　　金：哈尔滨市青年科学基金资助项目(0060218030)~~

摘　　要：目的:观察基底膜的主要组成蛋白Ⅳ型胶原和层粘连蛋白与2型糖尿病血管病变和血糖变化的关系。方法:选择1999/2003哈尔滨市第一医院收治的82例2型糖尿病患者,按有无血管病变分为大血管病变组(n=8),微血管病变组(n=36)和无并发症组(n=38);以44例正常人为正常对照组。用放射免疫法测定所有被试者的血清Ⅳ型胶原和层粘连蛋白水平,同时测定患者空腹血糖、糖化血红蛋白、胆固醇、等相关生化指标,用相关和多元回归分析各指标间相关性。结果:按意向处理分析,126例被试者全部进入结果分析。①血清Ⅳ型胶原水平:糖尿病组明显高于正常对照组犤(98.69±26.67)(78.41±19.12)μg/L,P<0.01犦;其中微血管病变组高于其他各组(P<0.01)。②血清层粘连蛋白水平:糖尿病组明显高于正常对照组犤(172.78±25.69),(147.02±27.64)μg/L,P<0.01犦;其中微血管病变组高于其他各组(P<0.01)。③不同病程糖尿病患者比较:各病程组间(<5年,5～,≥10年)的血清Ⅳ型胶原水平虽逐渐递增,但无差异(P>0.05)。病程6～10年及11～22年的患者血清层粘连蛋白水平高于正常对照组,亦高于病程<1年及1～5年者(P<0.01)。④不同血糖值的糖尿病患者比较:三组(<8,8～,≥11.1mmol/L)血清层粘连蛋白与Ⅳ型胶原值均高于正常对照组(P<0.01),但组间无差异。⑤2型糖尿病患者的血清Ⅳ型胶原和层粘连蛋白水平与血糖、病程呈正相关(P<0.01,0.05)。⑥血清Ⅳ型胶原和层粘连蛋白水平呈显著正相关(r=0.58,P<0.001)。结论:血清Ⅳ型胶原和层粘连蛋白水平与2型糖尿病微血管并发症的发生、发展及血糖的变化密切相关。AIM： To study the relationship between collagen IV that is the main component of basement membrane and laminin with vessel lesion of type 2 diabetes and changes of glucose. METHODS： Eighty-two type 2 diabetes patients treated at the Harbin First Hospital between 1999 and 2003 were selected. According to with or without vessel lesion, there were great vessel lesion group （n =8）, microvessel lesion group （n=36） and non-complication group （n=38）; Forty- four normal people were normal control group. The levels of serum IV collagen and laminin were detected with radio-immunity method. Meanwhile, fasting glucose, glucose ferrohemoglobin, cholesterol, etc. were tested. Correlation of every index was analyzed with related and multiple regression analysis. RESULTS： According to intention-to-treat analysis, 126 testees were all involved in the result analysis. （1） Level of serum collagen Ⅳ： It was higher significantly in the diabetes group than that in the normal control group [（98.69±26.67）（78.41±19.12）μg/L,P 〈 0.01]; It was higher in the microvessel lesion group than that in the other groups （P 〈 0.01）. （2） Level of serum laminin： It was higher obviously in the diabetes group than that in the normal control group [（172.78±25.69）, （147.02±27.64）μg/L,P 〈 0.01], in which it was higher in the microvessel lesion group than that in the other groups （P 〈 0.01）. （3） Comparison of diabetes patients in different course： Level of serum collagen Ⅳ increased gradually, but had no difference （P 〉 0.05 ） in groups of different course （〈 5 years,5-,≥ 10 years）. The level of serum laminin in patients at 6-10 years and 11-22 years was higher than that in the normal control group, and also higher than that in patients at 〈 1 year and 1-5 years （P 〈 0.01 ）. （4） Comparison of diabetes patients with different glucose value： The levels of serum laminin and collagen IV in the three groups （〈 8,8-,≥ 11.1mmol/L）were all higher tha

关 键 词：胶原Ⅳ型 层粘连蛋白 糖尿病血管病变 血糖 

分 类 号：R587.1[医药卫生—内分泌]