低应力环境对大鼠股骨的骨密度和几何形态学的影响  

Effect of Low Stress Environment on Bone Density and Geome-morphology of Rat Femur

作　　者：刘迎曦[1] 赵文志[1] 张军[1] 李守巨[1] 李靖年[2] 孙晓江[2] 

机构地区：[1]大连理工大学工程力学系工业装备结构分析国家重点实验室,大连116024 [2]大连医科大学第二临床学院骨科,大连116025

出　　处：《生物医学工程学杂志》2005年第6期1165-1167,共3页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(10472025);辽宁省自然科学基金资助项目(20032109)

摘　　要：切断6周大鼠的坐骨神经,使其右后肢处于低应力环境中。测量股骨不同部位的骨密度和几何形态学参数。结果发现,低应力环境下大鼠股骨的直径、皮质骨面积和骨矿密度的增加明显受抑制。但不同部位的骨密度对低应力环境的敏感性不同,表现为早期富于松质骨的股骨干骺端骨密度增加幅度的受抑,接着是富于皮质骨的骨干部的骨密度增长幅度的降低。几何形态学结果提示,早期干骺端骨密度增长幅度的降低是由于骨吸收增强,而皮质骨的骨量和尺寸的增长受抑制是骨膜骨形成持续减少的结果。6-week old rats were subjected to sciatic nerve resection and the right hindlimbs were then under a low stress environment, Bone mineral density（BMD） of different regions and geome-morphological parameters of femurs were measured. The results showed that the increase in the diameter, subperiosteal area and bone mineral density of femurs were suppressed obviously under low stress environment. But the sensitivity of BMD of different regions of the femur to the low stress environment was different, The suppression of the increase in femoral BMD was composed of an early impairment in the gain of BMD at the femoral metaphysis, which is rich in trabecular bone, and a sustained reduction in the gain of BMD at the femoral diaphysis, which is rich in cortical bone. The results of geome-morphology suggested that the early reduction in the increase of BMD at the metaphysis was due to an enhancement of bone resorption, whereas the suppression of gain in cortical bone mass and size is the result of a sustained reduction of periosteal bone formation.

关 键 词：低应力环境 骨密度 骨形态学 

分 类 号：R318.01[医药卫生—生物医学工程]