不同强度脉冲电磁场对兔股骨骨密度及生物力学特性的影响  

Effects of the PEMFs of Different Intensity on BMD and Biomechanical Properties of Rabbits' Femur

作　　者：罗二平[1] 焦李成[1] 申广浩[2] 吴小明[2] 徐巧玲[2] 路丽华[2] 

机构地区：[1]西安电子科技大学电子工程学院智能信息处理研究所,西安710071 [2]第四军医大学生物医学工程系军队卫生装备与计量学教研室,西安710033

出　　处：《生物医学工程学杂志》2005年第6期1168-1170,共3页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(50377044)

摘　　要：探讨了低强度脉冲电磁场对兔股骨骨密度及生物力学特性的影响。用27只雌性新西兰大耳白兔随机分为三组(n=9),磁场组暴露于强度分别为10×10-4、20×1-0 4T的脉冲磁场环境中(f=15 H z,=τ5 m s),暴磁时间为6 h.-d 1,对照组饲养于线圈中,但不暴磁。6周后处死取股骨,测定骨密度及生物力学特性。结果表明:与对照组比较,磁场组的骨密度、最大载荷及结构刚度差异具有显著性意义(P<0.05);其中,两个磁场组之间作比较,骨密度及结构刚度差异显著(P<0.05)。低强度脉冲电磁场能改善股骨的骨密度和生物力学性质,其生物效应存在明显的窗口效应,对骨质疏松症的预防和治疗提供了新的思路。The effects of the pulsed electromagnetic fields（PEMFs） of different intensity on bone mineral density（BMD） and biomechanical properties of rabbits＇ femur had been studied. Twenty-seven female white big ear rabbits were randomly divided into three groups. The magnetic groups were fed in 15 Hz PEMFs ,which pulse duration was set to be 5 ms （6 h · d^-1）, the magnetic intensity was 10×10^-4 T and the other was 20×10^-4 T. Control group were just fedin coils, and the instrument of PEMFs was powered off. After six weeks, by examine BMD and biomechanical properties of the rabbits＇ femur, control group, the values of BMD, maximum load and the effects of thesePEMFs were studied. Compared with structural rigidity of magnetic group were significantly increased（P〈0.05）. In addition, there was significant increase in values of BMD and structural rigidity in group 10×10^-4 T in comparison with group 20× 10^-4 T （P〈0. 05）. PEMFs is effective in improving BMD and biomechanical properties. The experiment indicated that there was evident “window-effect” during the treatment by PEMFs. It is favorable to the treatment and prevention of osteoporosis.

关 键 词：脉冲电磁场 兔 骨密度 生物力学 

分 类 号：R35[医药卫生—基础医学]