成人隐匿性自身免疫性糖尿病与HLA-DQ、DR基因的关联性  

The relationship between latent autoimmune diabetes in adult(LADA) and HLA-DQ and DR gene

作　　者：李强[1] 潘红艳[1] 陈莉丽[1] 乔虹[1] 孙玉倩[1] 梁玮[1] 张巾超[1] 

机构地区：[1]哈尔滨医科大学附属二院内分泌代谢病科,150086

出　　处：《中华糖尿病杂志（1006-6187）》2005年第6期432-433,436,共3页

基　　金：哈尔滨市科技攻关项目基金资助项目(9814211018);黑龙江省卫生厅科研课题资助项目(2001-024)

摘　　要：探讨成人隐匿性自身免疫性糖尿病(LADA)与HLA-DQ、DR基因的关联性。方法用聚合酶链反应序列特异性引物(PCR-SSP)检测60例正常人、41例1型糖尿病人(TlDM)和39例LADA患者的HLA-DR、DQ基因频率。结果HLA-DR3、DR4、HLA-DQA10301、HLA-DQB10201与TlDM的易感性相关;HLA-DR15、HLA-DQB10601与TlDM的保护性相关。HLA-DR4、HLA-DQA10301、HLA-DQB10201与LADA的易感性相关,HLA-DQB10601的基因频率在LADA组中显著高于TlDM组(P<0.05)。结论不同的遗传背景可能是影响LADA和TlDM起病方式及病情进展的重要因素之一。Objective The relationship between LADA and HLA- DQ and DR genes was stud- ied. Methods The genotypes of HLA-DR and DQ in 60 healthy controls, 41 patients with type 1 diabetes, 39 patients with LADA were determined by PCR-SSP. Result （1） HLA-DR3,DR4, HLA-DQA1 ＊ 0301 ,DQB1 ＊ 0201 were positively associated with type 1 diabetes; HLA-DR15, HLA-DQB1＊ 0601 were negatively associated with type 1 diabetes. （2）The frequencies of HLA-DR4, HLA-DQ＊0301, HLA-DQB1 ＊ 0201 were positively associated with LADA,and the frequencies of HLA-DQB1＊ 0601 were significantly higher in LADA group than those in type 1 diabetic group. Conclusion Different genetic background may influence the progression of LADA and type 1 diabetes.

关 键 词：糖尿病 1型 成人隐匿性自身免疫性糖尿病 HLA-DQ基因 HLA-DR基因 

分 类 号：R587.1[医药卫生—内分泌] R587.103[医药卫生—内科学]