血管紧张素多成员系统及各成员相互作用  

Family of multiple peptide fragments derived from angiotensin and their interaction

作　　者：蒲丹[1] 唐朝枢[1] 

机构地区：[1]北京大学第一医院心血管研究所,北京100034

出　　处：《北京大学学报（医学版）》2005年第6期661-665,共5页Journal of Peking University:Health Sciences

基　　金：国家重大基础研究发展规划"973"项目(G200056900);国家自然科学基金(30170347)资助~~

摘　　要：It is well established that renin-angiotensin system (RAS) is the major regulatory networkthat maintains blood pressure, fluid and electrolyte balance and the homeostasis of cardiovascular system.Most studies in the last decades centered on the pivotal members of RAS, that is, angiotensinⅡ (AngⅡ) and angiotensin converting enzyme (ACE). Recent identification of ACE-2, the homology of ACE,and the identification of the multiple products degraded from angiotensinⅠ, including AngⅢ, AngⅣ,Ang1 -9, Ang1 -7, Des-Asp-angiotensinⅠ(DAAⅠ), etc, have proved that AngⅡ is not the only bio-logical active compound of RAS. Peptides derived from angiotensinogen,that is, family of angiotensins,display independent and pleiotropic biological activitiesin vivo, and interact with each other both in me-tabolism pathway and the biologic effects. The imbalance of the network of angiotensin metabolites exhib-its significant pathophysiological role in cardiovascular disease.It is well established that renin-angiotensin system （RAS） is the major regulatory network that maintains blood pressure, fluid and electrolyte balance and the homeostasis of cardiovascular system. Most studies in the last decades centered on the pivotal members of RAS, that is, angiotensin Ⅱ （Ang Ⅱ） and angiotensin converting enzyme （ACE）. Recent identification of ACEo2, the homology of ACE, and the identification of the multiple products degraded from angiotensin Ⅰ , including Ang Ⅲ, Ang Ⅳ, Angm-9, Angm-7, Des-Asp-angiotensin Ⅰ （DAA Ⅰ ）, etc, have proved that Ang Ⅱ is not the only biological active compound of RAS. Peptides derived from angiotensinogen, that is, family of angiotensins, display independent and pleiotropic biological activities in vivo, and interact with each other both in metabolism pathway and the biologic effects. The imbalance of the network of angiotensin metabolites exhibits significant pathophysiological role in cardiovascular disease.

关 键 词：肾素-血管紧张素系统 心血管疾病 代谢 

分 类 号：R589.3[医药卫生—内分泌]