^(188)Re液体充盈球囊防治冠脉支架植入后血管再狭窄  

Preventing Coronary Restenosis after Stent with ^(188)Re Liquid-Filled Balloon

作　　者：程旭[1] 黄钢[1] 王庆胜[2] 李殿富[3] 柳东田[2] 陶如琦[2] 刘建军[1] 刘建平[4] 孙晓光[1] 

机构地区：[1]上海第二医科大学仁济医院核医学科 [2]秦皇岛市第一医院心内科 [3]南京医科大学第一附属医院心脏科核心脏病学研究室 [4]上海第二医科大学仁济医院心内科

出　　处：《上海第二医科大学学报》2005年第12期1280-1283,共4页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：上海市科委基金(034119823);上海市百人计划(97BR012)资助项目.

摘　　要：目的探讨临床应用^(188)Re液体充盈球囊防治支架植入后冠脉血管再狭窄的安全性、有效性和可行性。方法7例患者接受冠状动脉支架植入术者进行^(188)Re液体充盈球囊冠脉内近距离放射治疗,并在支架植入及幅射治疗前1周内、治疗后1周内和治疗后6个月时行门控核素心肌灌注显像,利用核素心肌显像对血管再狭窄情况进行评价。结果7例患者接受幅射治疗时间为(6.20±1.55)min,以保证距离血管内壁0.5mm处的组织辐射吸收剂量为17.5~20Gy。全部患者在术中无1例出现严重不良反应、球囊破裂、^(188)Re放射性溶液进入血循环及泄漏等事件。6例随访核素心肌显像示灌注异常均较术前改善,支架内再狭窄发生率为14.3%(1/7)。结论^(188)Re液体充盈球囊防治冠脉血管再狭窄具有较高的安全性、有效性和良好的可行性,有重要的临床应用价值。Objective To investigate the clinical safety, effect and feasibility of preventing restenosis after stent with ^188Re liquid-filled balloon. Methods Seven patients underwent coronary stenting underwent brachytherapy with ^188Re liquid-filled ballon. All patients performed radionuclide gated myocardial perfusion imaging before, within one week and six months after brachytherapy respectively for the assessment of restenosis. Results The time duration of radiation exposure in brachytherapy was （6.20 ± 1.55） rain in average. Non of the patient occurred serve side effect during procedure including balloon rapture, leakege of the ^188Re radioactivity into circulation events etc. The incidence of restenosis within the stent was 14.3% （ 1/7 ）. Conclusion The brachytherapy using ^188Re liquid-filled balloon was a safe, effective and feasible method in preventing restenosis within stent and also it has important clinical value.

关 键 词：再狭窄 近距离放射治疗 体层摄影术 发射型计算机 单光子 ^188Re液体 

分 类 号：R541.4[医药卫生—心血管疾病]