胆固醇改性聚硅氧烷的合成和血液相容性  

Synthesis and hemocompatibility of liquid crystalline polysiloxane with cholesterol in side chain

作　　者：王晓丽[1] 计剑[1] 徐建平[1] 沈家骢[1] 

机构地区：[1]浙江大学

出　　处：《材料研究学报》2005年第6期608-612,共5页Chinese Journal of Materials Research

基　　金：国家高技术研究发展计划2001AA326030资助项目~~

摘　　要：合成了胆固醇基团直接键合和通过长链烷基柔性链键合的胆固醇-聚硅氧烷接枝共聚物,研究 了胆固醇改性聚硅氧烷的血液相容性．结果表明,未经长链烷基键合的共聚物不能形成液晶相,而经长链烷 基键合的共聚物可以形成热致液晶．侧链液晶聚硅氧烷的液晶结构和材料的血液相容性具有独特的依赖性, 热处理后形成的液晶相有助于提高材料的血液相容性．Liquid crystalline （LC） polysiloxane with cholesterol group in side chain was prepared by a dehydrogenation reaction of poly（hydrogenmethylsiloxane） with cholesterol（SC0） or with terminal hydrogen of cholesterol decyl ether（SC10）. The structures purification of these polymers was confirmed by analysis of FTIR and proton nuclear magnetic resonance （^1H-NMR）. SC0 did not form liquid crystalline, while SC10 with flexible spacer formed LC, and the LC transform temperature was about 124.9 T3. The anneal-quenched film （SC10） formed continuous LC phase, whereas the unannealed films presented amorphous structure. The biocompatibility of the coating was evaluated using the platelet-adhesion test and the plasma recalcification time （PRT）. The platelet＇s adhesion to coating surface was assessed by SEM observation. The results showed that the formation of LC phase could improve the hemocompatibility of the materials.

关 键 词：有机高分子材料 聚硅氧烷 胆固醇 液晶 血液相容性 

分 类 号：TB324[一般工业技术—材料科学与工程]