男性甲亢患者治疗前后血清性激素水平观察  

The Observation of Serum Sexual Hormone Levels Before and After Treatment in Male Hyperthyroidisms

作　　者：郑铁生[1] 叶立新[2] 吴志勇[2] 

机构地区：[1]江苏大学医学技术学院 [2]江苏大学附属医院内分泌科,江苏镇江212001

出　　处：《中华男科学杂志》2005年第12期936-938,共3页National Journal of Andrology

摘　　要：目的:探讨男性甲亢患者治疗前后血清性激素水平的变化及其临床意义。方法:采用化学发光免疫法测定68例男性甲亢患者治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)和雌二醇(E2)的水平,并与对照组比较,进行统计学分析。结果:男性甲亢患者治疗前血清T和E2的水平明显高于对照组,差异有显著性(P<0.05);FSH、LH的水平与对照组相比差异无显著性(P>0.05)。男性甲亢患者治疗后血清FSH、LH、T和E2的水平与对照组相比差异无显著性(P>0.05)。结论:男性甲亢患者存在性激素代谢紊乱;患者血清T和E2水平的增高是机体为了适应高代谢环境,下丘脑-垂体-性腺轴所产生的适应性变化;随着甲亢得到控制,其水平恢复正常。Objective ： To explore the changes of serum sexual hormone levels in male hyperthyroidisms before and after treatment, Methods ： Compared with the control group, the serum follicle-stimulating hormone （FSH） , leuteinizing hormone （LH） , testosterone （T） and estradiol（ E2 ） of 68 cases of male hyperthyroidisms before and after treatment were detected by chemiluminescence immunoassay technique, and then statistical analysis was performed. Results ： The serum T and E2 levels of male hyperthyroidisms were significantly higher than those of the control group before treatment（ P 〈 0.05 ） ; while no significant difference in FSH and LH levels existed between the patients and the control group（ P 〉0.05 ）. There was no difference in FSH, LH, T and E2 levels between patients and the control group after treatment（P 〉0.05）. Conclusion： There are sexual hormone metabolism disorder in hyperthyroidism men, and the increasing serum T and E2 levels are only to adapt the high metabolism environment, and the changes of hypothalamus-pituitary-gonadal axes. Along with the control of hyperthyroidism, the sexual hormone levels return to normal. Natl J Androl,2005,11 （12） ： 936-938

关 键 词：甲状腺功能亢进 性激素 高代谢 适应性 男性 血清 

分 类 号：R581.1[医药卫生—内分泌]