2型糖尿病患者氧自由基与微血管病变的关系  

The Role of Oxygen Free Radical in The Diabetic Microangiopahy

作　　者：张淑华[1] 王琳[2] 汪莼[2] 

机构地区：[1]同济大学附属第十人民医院老年科,上海200072 [2]同济大学附属第十人民医院内分泌科,上海200072

出　　处：《同济大学学报（医学版）》2005年第6期45-46,共2页Journal of Tongji University(Medical Science)

摘　　要：目的探讨2型糖尿病患者氧自由基与微血管病变的关系。方法2型糖尿病患者62例,男30例,女32例,平均年龄(51.2±5.6)岁,其中28例合并微血管病变,(糖尿病肾病者12例,糖尿病视网膜病变者16例),正常对照组:体检健康人60例,男29例,女31例,平均年龄(52.8±7.6)岁,2组人员分别作糖化血红蛋白(glycosylatedhemoglobinA1,HbAIc)、血清脂质过氧化物(serumlipidperoxisome,LPO)、超氧化物歧化酶(superoxidedismutate,SOD)、一氧化氮(NitricOxide,NO)测定。结果2型糖尿病患者HbAIc、LPO、NO水平比正常对照组升高(P<0.01),SOD降低;伴有血管并发症者的HbAIc、LPO、NO比无血管并发症者升高更显著,SOD降低更明显。结论2型糖尿病患者氧自由基与微血管病变有一定关系。Objeetive To explore the role of oxygen free radical in the diabetic microangiopathy. Methods The diabetic group; 60 patients of type- 2 diabetes mellitus - 30 male, 30 female, average aged （52.2 ± 4.6 ）-among them 38 patients complicated with microangiopathy. 20 out of the 28 cases has diabetic nephropathy, and 18 out of the 28 cases has diabetic retinopathy. The control group： 60 healthy cases - 29 male, 31 female, average aged （51.4 ± 5.6）. Respectively assay the following indexes in the patients of two groups： glycosylated hemoglobin A1 （Hb A1c）、serum lipid peroxisome （LPO）、superoxide dismutate （SOD） and nitric oxide （NO）. Results The level of HbAIc、LPO and NO are higher in type - 2 diabetic patients than those in the control group （P〈0.01）, while the level of SOD is lower; in the diabetic angiopathic patients, the increase of HbAIc、LPO、 NO and the decrease of SOD are significant than those in the diabetic patiens without angiopathy. Conclusion Oxygen free radical plays a role in genesis and progressing of the type-2 diabetic microangiopathy.

关 键 词：糖尿病 脂质过氧化物 超氧化物歧化酶 一氧化氮 氧自由基 微血管病变 

分 类 号：R587.1[医药卫生—内分泌]