4-氨基吡啶对鼠胃肠道功能的影响  

Effects of 4-aminopyridine on the gastrointestinal function of murine

作　　者：王庆徽[1] 董德利[1] 杨宝峰[1] 

机构地区：[1]哈尔滨医科大学药理学教研室

出　　处：《中国药理学通报》2005年第12期1470-1473,共4页Chinese Pharmacological Bulletin

基　　金：黑龙江省自然科学基金资助项目(NoD0246)

摘　　要：目的观察钾通道阻滞剂4氨基吡啶(4AP)对于鼠胃肠道功能的影响。方法水溶性炭末法检测小鼠胃肠蠕动;多通道生理记录仪记录大鼠胃肠纵形肌条张力参数;胃酸分泌实验检测大鼠胃酸分泌。结果4AP(5mg·kg-1,ig)抑制小鼠胃肠推进,4AP(5mmol·L-1)能增加大鼠十二指肠最大收缩力和最小舒张力,使收缩幅度减小、频率降低;4AP(2.5mg·kg-1,ip)促进大鼠胃酸分泌。结论4AP对鼠类胃肠运动功能有抑制作用,对大鼠胃酸分泌功能有促进作用。Aim To investigate the effects of 4-aminopyridine （4-AP） , K^＋ channel blocker, on the gastrointestinal function of murine. Methods Charcoal suspension was used to detect the effects of 4-AP on gastrointestinal motility of mice in vivo, contraction of isolated fundus longitudinal strips and duodenum of rats were studied in vitro, gastric acid secretion was measured by Gastric Secretion Test. Results 4-AP（5 mg · kg^-1, ig ） inhibited the gastrointestinal motility of mice. 4-AP（5 mmol · L^-1） increased the maximum contractive force and creased the amplitude minimum relaxation force, deand frequency of the isolated duodenum peristaltic contraction. 4-AP （2. 5 mg · kg^- 1, ip） significantly enhanced gastric acid secretion of rats. Conclusion 4-AP inhibited gastrointestinal motility and enhanced gastric acid secretion in murine.

关 键 词：4-氨基吡啶 胃肠功能 鼠类 

分 类 号：R-332[医药卫生] R322.4