雪旺氏细胞在周围神经损伤修复中的作用及其分子机制  

Role of Schwann cell and its Molecular Mechanism during the Regeneration of Peripheral Nerves

作　　者：何晶[1] 丁文龙[1] 

机构地区：[1]上海第二医科大学解剖学教研室,上海200025

出　　处：《解剖科学进展》2005年第4期367-372,376,共7页Progress of Anatomical Sciences

基　　金：上海市高等学校技术发展基金项目(No.03BK15);上海市教委第四期重点学科资助项目(ZDXK2001)

摘　　要：雪旺氏细胞是周围神经系统中特有的胶质细胞,在周围神经损伤后的变性和再生中有着非常重要的作用。周围神经的再生主要依赖于雪旺氏细胞提供了适宜的微环境,如分泌多种神经营养因子和其它相关因子,位于轴突和雪旺氏细胞之间的紧密连接加强信息传递,雪旺氏细胞形成Büngner带为轴突生长的通道,并形成髓鞘等。本文阐述了雪旺氏细胞在周围神经再生中的重要功能以及相关机制,展望围绕雪旺氏细胞的未来研究方向,临床应用的潜在价值。Schwann cells are the glial cells in peripheral nerve system, which play a key role in wallerian degeneration and subsequent regeneration, and provide a suitable environment for regeneration. The underlying cellular mechanism of regeneration is based on the interactions between axons and schwann cells involving the production of neurotrophic factors and other related molecules, tight junctional contact between the axon and Schwann cell, formation of Bttngner bands and remyelination. In this article, the important role of the schwann cell and the possible mechanism during the regeneration of peripheral nerves is explained. At last, this article describes the trend of researches around Schwann cells and clinical application in future.

关 键 词：周围神经系统 雪旺氏细胞 分子机制 损伤修复 周围神经再生 周围神经损伤 神经营养因子 轴突生长 胶质细胞 相关因子 

分 类 号：R651.3[医药卫生—外科学] R735.7[医药卫生—临床医学]