类脂囊泡作为头孢派酮药物载体的研究  

Study on Niosomes as Cefoperazone Drug Carrier

作　　者：杜美菊[1] 丁秀云[1] 李娜[2] 赵凤林[2] 李克安[2] 

机构地区：[1]商丘师范学院,河南商丘476000 [2]北京大学化学与分子工程学院,北京100871

出　　处：《河南化工》2005年第12期16-18,共3页Henan Chemical Industry

摘　　要：用司盘(Span)系列非离子表面活性剂和胆固醇(CH)通过真空旋转—超声波法制备了头孢派酮囊泡,研究了包封条件对包封率的影响及包封后的药物在体外的模拟释放。实验表明:Span6 0与CH物质的量比为4∶3,50℃超声50 m in,对1.00 g/L的注射用头孢派酮的包封率可达60%以上,而且在模拟肠流体和模拟胃流体中均有缓释作用。Cefoperazone was encapsulated in niosomes formed by non - ionic surfactant Span and cholesterol via an evaporation - sonication method. To obtain a higher encapsulation efficiency, factors including the structure of the surfactant, sonicaton, content of the drug and cholesterol were investigated and optimized. Furthermore, the release behavior of cefoperazone encapsulated in the niosome in simulated gastric and intestinal fluid was studied. The results showed that the entrapment efficiency of the niosomes for cefoperazone could be as high as 60% under the following experimental conditions： drug concentration 1.00g/L, molar ratio of Span60 to cholesterol 4 ： 3 and sonication for 50 min at 50℃. The release profiles in simulated gastric and intestinal fluid showed a controlled release tendency to some extent.

关 键 词：类脂囊泡 药物载体 头孢派酮 

分 类 号：R944[医药卫生—药剂学]