石杉碱甲乳酸-羟基醋酸共聚物微球的加速释放度试验研究  

Study on accelerated release testing method of huperzineA PLGA microspheres

作　　者：符旭东[1] 高永良[1] 平其能[2] 汤韧[3] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]中国药科大学药学院,江苏南京210090 [3]广州军区武汉总医院,湖北武汉430070

出　　处：《中国医院药学杂志》2005年第11期1005-1008,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:建立石杉碱甲微球的加速释放度试验方法。方法:通过考察温度和释放介质的pH对石杉碱甲微球释药速度的影响,确定体外加速释放的条件。通过相关性评价建立加速与长期释放度数据的回归方程。结果:加速释放度与长期释放度数据之间具有良好的非线性相关(r2=0.994 8),可以通过加速释放度数据较好地预测长期释放度数据。结论:加速释放度试验可用于快速评价石杉碱甲微球的释药特性。OBJECTIVE To develop the accelerated release testing method. METHODS The accelerated release condition of huperzineA PLGA microspheres was established by examining the effects of temperature and the medium pH on huperzineA released from microspheres. The regression equation was built by correlation evaluation of accelerated release data and long term release data RESULTS Accelerated release rate correlated well with long release rate（r^2〉0. 998 9, P〈0. 01 ）. Long term release rate could be predicted by accelerated release rate. CONCLUSION Accelerated release testing could be applied to evaluate the drug release profile of huperzineA PLGA microspheres.

关 键 词：石杉碱甲 微球 乳酸-羟基醋酸共聚物 体外释放度 加速试验 

分 类 号：R965[医药卫生—药理学]