肝毒清颗粒对致炎细胞因子的调节作用  

The sduty on adjusting effect on cytokines of Ganduqing granules

作　　者：李晓冰[1] 李万平[1] 肖顺汉[1] 李华[1] 陈美娟[1] 李亮[1] 

机构地区：[1]泸州医学院药理教研室,四川泸州646000

出　　处：《中国医院药学杂志》2005年第11期1024-1026,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察肝毒清颗粒对急性肝损伤的保护作用。方法:选用WISTER♂大鼠60只,随机分为6组,即空白对照组、模型组、肝毒清颗粒大、中、小剂量组,乙肝宁阳性对照组。用硫代乙酰胺复制急性肝损伤模型。检测血清肿瘤坏死因子(TNF-α)、白介素-6(IL-6)水平。结果:硫代乙酰胺急性肝损伤时,肝毒清颗粒能使血清TNF-α、IL-6水平明显降低,与模型组比较,差异有显著性(P<0.05)。结论:肝毒清颗粒能减少致炎细胞因子的生成,减轻致炎细胞因子的肝损害,对肝脏起到保护作用。OBJECTIVE To observe the protective effect of Oanduqing granules（ODQ） on acute hepatic injury. METHODS Sixtymale Wistar rats were divided into 6 groups, namely normal control group, model group, Ganduqing large, middle, small dose groups and Yiganning（YGN） positive group. Acute hepatic injury was induced by thioacetamide. The changes of blood serum TNF-α, IL-6 level were measured. RESULTS TNF-α,IL-6 levels were significantly lower than model group（P〈0. 05）. CONCLUSION Ganduqing granules can reduce the creation of causing inflammation cytokines. Lighten cytokines leading hepatic injury and protect the liver when the liver was injured.

关 键 词：肝毒清 大鼠 肝损伤 细胞因子 

分 类 号：R285.5[医药卫生—中药学]