西替利嗪凝胶的制备和质量评价  

The preparation and the quality assessment of cetirizine gel

作　　者：陈腾[1] 李世根[1] 苏锡谭[1] 

机构地区：[1]武警广东总队医院,广东广州510507

出　　处：《中国医院药学杂志》2005年第8期740-741,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的:制备西替利嗪凝胶剂,并建立质量控制方法。方法:以卡波姆940为基质制备凝胶,采用紫外分光光度法测定西替利嗪含量,并考察其稳定性。结果:西替利嗪线性范围为6～16mg·L-1(r=0.9967),平均回收率为98.23%,RSD为0.69%(n=5),凝胶稳定性良好。结论:该凝胶制备工艺可行,性质稳定。OBJECTVIE To prepare cetirizine gel and establish a quality control method for the gel. METHODS Carbopol 940 was used the gel base, the content of cetirizine was determined with UV-spectrophotometry and the stability test was performed. RESULTS There was a good linearity of calibration curve of cetirizine in range of 6-16 mg·L^-1 ,r= 0. 996 7,the average recovery was 98. 23%. RSD was 0. 69% （n= 5） The gel was stable. CONCLUSION The design of the gel formulation is reasonable. The gel can be prepared feasibly and is stable in quality, convenient in use.

关 键 词：西替利嗪 凝胶剂 制备 质量评价 

分 类 号：R944.7[医药卫生—药剂学]