环钯-[PPh_4]Br体系催化氯代芳烃的Heck芳基化反应研究  

Study on the Heck Reaction of Chlorobenzene Catalyzed by Palladacycle-[PPh_4]Br

作　　者：周浩[1] 卓广澜[1] 姜玄珍[1] 

机构地区：[1]浙江大学化学系,浙江杭州310027

出　　处：《分子催化》2005年第6期490-494,共5页Journal of Molecular Catalysis(China)

基　　金：国家自然科学基金资助项目(20476092)

摘　　要：以氯代芳烃为底物,季鏻盐[PPh4]B r为助催化剂,用于环钯催化的Heck芳基化反应.结果表明,在环钯-[PPh4]B r催化体系中,以Na2CO3作为碱性试剂,使用0.3 mol%Pd的环钯催化剂催化氯苯的Heck反应,就可得到比较高的产率(88%)和转化率(90%).对于大部分卤代芳烃Heck反应而言,环钯-[PPh4]B r是一种有效的催化体系,即使是对含推电子基团的不活泼的氯代芳烃,在此体系中也能获得比较好的结果.此外,文中还探讨了反应温度、[PPh4]B r/Pd比值及催化剂回用对反应活性的影响.In this study, it was described that a phosphonium salt, [ PPh4 ] Br, was used as co-catalyst in the palladacycle catalyst system for the Heck reaction of the aryl chlorides. In the Palladacycle-[ PPh4 ] Br catalyst system, the amount of 0.3 mol % palladium can afford high yield （88%） and conversion （90%） for the Heck reaction of chlorobenzene with styrene by using Na2CO3 as the base. Palladacycle-[ PPh4 ] Br is an efficient catalyst system for the most aryl halides, even some aryl chlorides with electron-donating groups. Moreover, the influences of reaction temperature, the ratio of [ PPh4 ] Br/Pd and recycling of catalyst on the reaction performances were also discussed.

关 键 词：环钯 HECK反应 氯苯 助催化剂 

分 类 号：O643.32[理学—物理化学]