新生儿HIE血浆ADM动态水平及临床意义  

Clinical Significance of Dynamic Determinations of Plasma Adrenomedullin Levels in Full-term Neonates with Hypoxid-Ischemic Encephalopathy

作　　者：张士发[1] 周名雄[1] 张新路[2] 杨军[2] 窦常胜[1] 李志奇[1] 

机构地区：[1]皖南医学院弋矶山医院儿科,241001 [2]皖南医学院弋矶山医院核医学科,241001

出　　处：《放射免疫学杂志》2005年第6期419-421,共3页Journal of Radioimmanology

摘　　要：目的:探讨新生儿缺氧缺血性脑病(hypoxic-ischem ic encephalopathy,H IE)血浆肾上腺髓质素(ad-renom edu llin,ADM)动态变化及临床意义。方法:采用非平衡放射免疫分析动态测定32例H IE新生儿生后24h、3d、7d血浆ADM水平,并以30例正常新生儿为正常对照组。结果:H IE组生后24h、3d、7d ADM浓度分别为(139.58±37.86)pg/m l、(121.97±35.73)pg/m l和(97.25±21.27)pg/m l,三者间差异显著(P均<0.05);与对照组(87.49±15.00)pg/m l比较,生后24h、3d明显增高,有显著性差异(P均<0.05),而7d与对照组比较无差异(P>0.05)。结论:ADM参与新生儿H IE的病理过程,且可能是机体在缺氧缺血性脑损伤时发生的一种自我保护机制。Abstract Objective To study the dynamic changes of plasma adrenomedullin （ADM） levels in full - term neonates with Hypoxic - ischemic encephalopathy （HIE）. Methods Plasma ADM levels were measured with RIA in 32 full - term neonates with HIE on 1 st, 3rd and 7th day after parturition, and in 30 controls. Results Plasma levels of ADM in neonates with HIE on 24h, 3d and 7d were 139.58 ± 37.86pg/ml, 121.97 ± 35.73pg/ml and 97.25 ± 21.27pg/ml respectively, differences between each other were all significant （P 〈 0.05）. The values at 24h and on d3 were significantly higher than those in controls （87.49 ± 15.00pg/ml, P 〈 0.05 ）, while those on d7 were not （vs control, P 〉 0.05 ）. Conclusion The increase of plasma ADH levels after the incident of HIE was probably an auto - protective regulatory process against the adverse effect of increase of ET, TNF - α and other cytokines.

关 键 词：缺氧缺血性脑病 新生儿 肾上腺髓质素 血浆 

分 类 号：R722.12[医药卫生—儿科] R743.3[医药卫生—临床医学]