2型糖尿病肾病患者血浆ET、Hcy测定的临床意义  

Clinical Significance of Determination of Plasma Endothelin(ET) and Homocysteine(Hcy) Levels in Patients with Diabetic Nephropathy

作　　者：张爱民[1] 靳颖[1] 周秀[1] 

机构地区：[1]武警医学院附属医院检验科,300162

出　　处：《放射免疫学杂志》2005年第6期434-435,共2页Journal of Radioimmanology

摘　　要：目的:探讨2型糖尿病肾病(DN)患者内皮素(ET)、同型半胱氨酸(Hcy)的浓度.方法:分别应用放射免疫分析、荧光法测定32例糖尿病无肾病组和35例糖尿病肾病组患者血浆ET、Hcy的含量,并与30名正常对照组进行比较.结果:2型糖尿病肾病组ET、Hcy的含量均明显高于正常对照组和糖尿病无肾病组(P＜0.05～0.01).结论:ET、Hcy均通过一系列复杂的机制参与了DN的发生和发展,它们对DN的预防和治疗将有重要的临床意义.Objective To determine the plasma levels of endothelin （ET） and homocysteine （Hcy） in patients with diabetic nephropathy. Methods Plasma ET （with RIA） and Hcy （with electrochemiluminescence） contents were determined in 32 DM2 patients without nephropathy, 35 DM2 patients with nephropathy and 30 controls. Results Endothelin and homocysteine levels were significantly higher in patients with diabetic nephropathy than those in patients without nephropathy and controls （ P 〈 0.05 - 0.01 ）. Conclusion Endothelin and homocysteine were involved in the pathogcnesis of diabetic nephropathy, and determination of which were of diagnostic and prognostic value in clinical practice.

关 键 词：2型糖尿病肾病 内皮素 同型半胱氨酸 血浆 放射免疫分析 

分 类 号：R692[医药卫生—泌尿科学] R587.1[医药卫生—外科学]