儿童肺结核病患者血清IL-2、SIL-2R和VEGF水平及临床意义  

Clinical Significance of the Changes of Serum IL-2,SIL-2R and VEGF Levels in Pediatric Patients with Pumorary Tuberculosis

作　　者：曾东良[1] 吴春凤[1] 姜焕好[1] 

机构地区：[1]广东省深圳市宝安区人民医院,518101

出　　处：《放射免疫学杂志》2005年第6期435-437,共3页Journal of Radioimmanology

摘　　要：目的:探讨了儿童肺结核病患者血清白细胞介素-2(IL-2)、可溶性白细胞介素-2受体(SIL-2R)和血管内皮生长因子(VEGF)水平的变化及意义。方法:分别应用放射免疫分析和ELISA对68例儿童肺结核病患者进行了血清IL-2、SIL-2R和VEGF水平观察,并与35名正常健康人作比较。结果:活动性儿童肺结核病患者血清IL-2水平显著低于正常儿组(P<0.01),而SIL-2R和VEGF水平显著高于正常儿组(P<0.01)。结论:测定儿童肺结核病患者血清IL-2、SIL-2R和VEGF水平更有助于儿童肺结核病活动性的检测,对该病的预防和预后均有一定的意义。Objective To explore the clinical significance of the changes of serum IL - 2, soluble IL - 2 receptor （ SIL - 2R） and vascular endothelial growth factor （VEGF） levels in pediatric patients with tuberculosis. Methods Serum IL -2 （with RIA） and SIL -2R, VEGF （with ELISA） levels were determined in 68 pediatric patients with tuberculosis （30 active and 38 non -active） and 30 controls. Results In the patients with active tuberculosis, the serum IL- 2 levels were significantly lower and SIL -2R, VEGF levels were significantly higher than those in the controls （ P 〈 0. 01 ）. Conclusion Determination of serum IL - 2, SIL - 2R and VEGF levels was useful for monitoring the activity of tuberculosis in pediatric patients.

关 键 词：儿童肺结核病 白细胞介素-2(IL-2) 白细胞介素-2受体(SIL-2R) 血管内皮生长因子(VEGF) 血清 

分 类 号：R521[医药卫生—内科学] R725.6[医药卫生—临床医学]