MDMA在急性染毒大鼠死后体内的再分布  

POSTMORTEM REDISTRIBUTION OF MDMA IN ACUTE POISONED RATS

作　　者：张蕾萍[1] 王玉瑾[1] 安健康[1] 王英元[1] 

机构地区：[1]山西医科大学法医学院,太原030001

出　　处：《中国药物依赖性杂志》2005年第5期338-342,共5页Chinese Journal of Drug Dependence

基　　金：山西省自然科学基金资助项目(编号20011066);山西高校科技研究开发项目(编号20041319);山西医科大学学生创新项目(编号:200437)

摘　　要：目的:探索死后MDMA再分布变化规律及温度对死后MDMA再分布的影响。方法:将急性染毒大鼠处死后,分别置于室温下(17℃)或冷藏(4℃)。并于死后0 h2、h、24 h、48 h采集心血、外周血及心肌、肝、脾、肺组织,用液-液萃取衍生化法和气相色谱-氮磷检测器(GC-NPD)检测MDMA含量。结果:大鼠死后48 h内,随死亡时间延长,室温下心血MDMA浓度呈升高趋势(P<0.05),肝MDMA浓度先升后降(P<0.05),心肌MDMA浓度无显著性变化(P>0.05)。在死后2-24 h内,脾MDMA浓度升高(P<0.05),肺MDMA浓度下降(P<0.05)。冷藏下血液中MDMA变化幅度较小(P<0.01);组织MDMA浓度在室温和冷藏下比较差异无显著性(P>0.05)。结论:MDMA在大鼠体内存在死后再分布现象,死后血药浓度在低温下较高温下稳定。Objective： To investigate the variety regulation of MDMA postmortem redistribution, and influence of temperature on postmortem redistribution in rats. Metethods： The acute MDMA poisoned rats were killed, and then left at ambient temperature of either 17℃ or 4℃. Samples including cardiac blood, femoral blood, cardiac muscle, liver, spleen and lungs were taken at 0 h, 2 h, 24 h or 48 h postmortem and extracted with liquid-liquid and derivation. MDMA levels were detected by gas chromatography with nitrogen phosphorus detector. Results： MDMA concentrations in cardiac blood showed a tendency of rising as the time went on under the temperature of 17℃（ P 〈 0.05） ;in the liver, the concentrations descended after going up flint（ P 〈 0.05） ; there was no obvious change in the myocardium （ P 〉 0.05）. During 2-24 h, MDMA level in spleen increased and in lungs reduced （ P 〈 0.05）. At 4℃, the variety of MDMA level in blood was relatively lower（P〈0.01）. No significant difference was observed in the tissues under different temperatures（P 〉 0.05）. Conclusion：The results prove the presence of MDMA postmortem redistribution in rats. There is different influence of temperature on blood and tissues at MDMA postmortem redistribution.

关 键 词：3 4-亚甲基二氧基甲基苯丙胺 死后再分布 温度 气相色谱 大鼠 血药浓度 

分 类 号：R965[医药卫生—药理学] R595.5[医药卫生—药学]