复方瑞康欣对吗啡依赖大鼠戒断症状和单胺类神经递质的影响  

EFFECT OF COMPOUND RUIKANGXIN ON WITHDRAWAL SYMPTOMS AND MONOAMINE NEUROTRANSMITTERS OF MORPHINE-DEPENDENT RATS IN BRAIN STEM AND SPINAL CORD

作　　者：吴明松[1] 王大忠[1] 李晓东[2] 罗素元[1] 汤贤春[1] 麦创富 

机构地区：[1]遵义医学院生物学教研室,遵义563003 [2]珠海瑞桦戒毒康复中心,珠海519070

出　　处：《中国药物依赖性杂志》2005年第6期425-427,433,共4页Chinese Journal of Drug Dependence

基　　金：受贵州省卫生厅科学技术基金(课题编号:D-211);广东省珠海市科技计划项目(项目编号:PC.2005.1092)资助

摘　　要：目的:观察复方瑞康欣对吗啡依赖大鼠戒断症状、脑干和脊髓单胺类神经递质的影响。方法:SD大鼠按剂量递增法皮下注射(sc)吗啡建立大鼠吗啡依赖模型。用复方瑞康欣灌胃(ig)5 d后经纳洛酮催瘾,观察戒断症状、脑干和脊髓NA,DA,5-HT和5-HIAA含量的变化。结果:复方瑞康欣能降低纳洛酮催促产生的戒断症状的评分值(P<0.01),能抑制吗啡依赖大鼠戒断后的体重丢失(P<0.05);降低脑干DA,NA,5-HT及5-HIAA的浓度(P<0.05),而对脊髓单胺类神经递质水平几乎无影响(P>0.05)。结论:复方瑞康欣对吗啡依赖大鼠具有一定治疗作用,能缓解纳洛酮催促产生的戒断症状。Objective. ： To study the effect of compound Ruikangxin （CR） on morphine - dependent withdrawal symptoms and monoamine neurotransmitters in brain stem and spinal cord of rats. Methods ：Morphine- dependent rat model was induced by administration（so） of morphine at a gradual increasing dosage, then treated with CR for five days. The withdrawal symptoms were scored after naloxone precipitation, and the NA, DA, 5 - HT and 5 - HIAA were tested by fluorospectrophotometry. Results ： CR attenuated the weight loss （ P 〈 0.05）, reduced the score of withdrawal symptoms（ P 〈 0.01）, and decreased the concentration of NA, DA, 5 - HT and 5 - HIAA in brain stem（ P 〈 0.05）, but there was no change in spinal cord（ P 〉 0.05）. Conclusion ： CR has curative effect on morphine - dependent rats and alleviate withdrawal symptoms which might be related to down- regulating the level of monoamine neurotmnsmitters in brain Stem.

关 键 词：复方瑞康欣 吗啡依赖 戒断综合征 单胺类神经递质 大鼠 

分 类 号：R285.5[医药卫生—中药学] R595.5[医药卫生—中医学]