HPV16、沙眼衣原体、生殖道支原体感染与子宫颈癌关系的研究  

Relationship Between Human Apillomavirus 16 Chlamydia Trachomatis,Mycoplasma Genitalium Infection and Cervical Cancer

作　　者：蔡昌金[1] 吴昌辉[1] 梁连辉[1] 储兵[2] 陈述文[1] 

机构地区：[1]广东省中山市疾病预防控制中心皮肤病防治所,中山528402 [2]广东省中山市人民医院病理科,中山528405

出　　处：《中国中西医结合皮肤性病学杂志》2005年第4期229-231,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：中山市科技计划资助项目(编号:2001C026)

摘　　要：目的研究人乳头瘤病毒16(humanpapillomavirus16,HPV16)、沙眼衣原体(Chlamydiatrachomatis,Ct)和生殖道支原体(Mycoplasmagenitalium,Mg)的感染在子宫颈癌发生发展的意义。方法聚合酶链反应法检测45例子宫颈癌、83例宫颈上皮内瘤样病变(CIN)和332正常宫颈组织中HPV16、Ct和Mg的表达。结果HPV16在子宫颈癌的表达与CIN组和正常宫颈组织的表达差异有高度显著性(P<0.01),CIN组的表达与正常宫颈组织的表达差异有高度显著性(P<0.01);Ct在子宫颈癌的表达与CIN组和正常宫颈组织的表达无显著性差异(P>0.05);Mg的在子宫颈癌的表达与CIN组和正常宫颈组织的表达无显著性差异(P>0.05)。HPV16的感染与Ct、Mg的感染无关。结论子宫颈癌的发生可能与HPV16感染有关,与Ct和Mg感染无关。Objective To study the association between human papillomavirus 16（HPV16）, Chlamydia trachomatis（Ct）, Mycoplasma genitalium （Mg） infection and cervical cancer. Methods Forty-five cases with cervical cancer, 83 cases with cervical intraepithelial neoplasia （CIN） and 332 health controls were sequentially enrolled in this study, and polymerase chain reaction was used to detect the infection of HPV 16, Ct and Mg. Results Expression of HPV 16 in cervical cancer was significantly higher than that in CIN group and health control group. Expression of HPV 16 in CIN was significantly higher than that in health control group. Expression of Ct and Mg among cervical cancer group, CIN group and health group showed no obvious differences. Conclusion This study indicates that cervical cancer may have relationship with HPV 16 infection, and it has no relationship with Ct and Mg infection.

关 键 词：子宫颈癌 人乳头瘤病毒16 沙眼衣原体 生殖道支原体 聚合酶链反应 

分 类 号：R691.3[医药卫生—泌尿科学] R737.33[医药卫生—外科学]