联合吸入糖皮质激素、β_2受体激动剂及M受体阻断剂治疗中、重度COPD的临床观察  

Inhalation of β_2-agonist,anticholinergics and glucocorticosteroid in patients with moderate to severe chronic obstructive pulmonary disease

作　　者：韩永涛[1] 姜鹏[2] 李玉[2] 

机构地区：[1]山东大学齐鲁医院药剂科,山东济南250012 [2]山东大学齐鲁医院呼吸内科,山东济南250012

出　　处：《山东大学学报（医学版）》2005年第12期1182-1184,共3页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨联合吸入糖皮质激素、β2受体激动剂、M受体阻断剂与单独吸入激素对中、重度慢性阻塞性肺疾病(chronicobstructivepulmonarydisease,COPD)患者的疗效及不良反应。方法:选取COPD患者210例,随机分为联合吸入组及对照组。联合吸入组采用丁地去炎松、福莫特罗、异丙托品联合吸入12个月,对照组则单独吸入丁地去炎松。期间记录患者的急性发作次数、住院次数、心电图、肺功能和咽拭子真菌培养以及圣·乔治生活质量评分。结果:联合吸入组在3、12个月时第1秒用力呼气量(FEV1.0)、住院次数、急性发作次数及生活质量明显优于对照组,两组之间咽部真菌、心电图之间差异无统计学意义(P<0.05)。结论:与单独吸入激素相比,联合吸入可减少中、重度COPD患者的急性发作次数,提高患者的生活质量,不良反应没有相应增加。Objective： To explore the effect on moderate or serve chronic obstructive pulmonary disease （COPD） respectively by inhalation of β2-agonist, anticholinergics and glucocorticosteroid and of glucocorticosteroid alone. Methods： Two hundred and ten patients with COPD were divided into two groups. One group had been using budesonide, formoterol and ipratropium bromide for 12 months （combination group）, the other budesonide alone （control group）. Times of acute episode, time of being in hospital,EKG, pulmonary functions of the patients had been recorded during these months. Results： The cultivation of Fungus and EKG were not significantly different between the two groups （P〉0.05）,while FEV on the 3 and 6 months, times of acute episode, the time of being in hospital and the life quality were superior in combination group to control group. Conclusion： Compared with glucocorticosteroid alone, inhalation of β2-agonist, anticholinergics and glucocorticosteroid in combination decreases times of acute episode and time of being in hospital and improves patients＇life quality, while it does nothing to side effects.

关 键 词：肺疾病 慢性阻塞性 Β2受体激动剂 糖皮质激素 M受体阻断剂 

分 类 号：R563[医药卫生—呼吸系统]