流动注射化学发光法测定吩噻嗪类药物的研究  

The Determination of Phenothiazines by a Flow-Injection Chemiluminescence Method

作　　者：韩小年[1] 唐玉海[1] 于春玲[1] 王楠楠[1] 熊迅宇[1] 

机构地区：[1]西安交通大学理学院化学系,西安710061

出　　处：《药物分析杂志》2005年第12期1527-1530,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:建立快速测定吩噻嗪类药物的化学发光新方法。方法:在盐酸介质中,吩噻嗪类药物能被硫酸铈氧化生成发光物质砜,从而产生化学发光。基于此,建立了吩噻嗪类药物的流动注射化学发光分析方法。结果:在优化的实验条件下,不用任何增敏剂,盐酸氯丙嗪、盐酸异丙嗪在1.0×10^(-7)～1.0×10^(-5)g·mL^(-1),奋乃静在1.0×10^(-7)～1.0×10^(-4)g·mL^(-1)范围内与化学发光强度呈良好的线性关系;检出限(3σ)分别为7.0×10^(-8)g·mL^(-1),5.0×10^(-8)g·mL^(-1),2.0×10^(-1)g·mL^(-1)。结论:本方法简便、快速、准确,灵敏度高、线性范围宽,该法应用于相应注射剂和片剂分析,结果令人满意。Objective：To establish a rapid and precise continuous flow-injection chemiluminescence method for the determination of phenothiazines drugs. Methods： In HCl medium, phenothiazines - chlorpromazine hydrochloride, promethazine hydrochloride and perphenazine could be oxidated by the ceriuim （IV） and chemiluminescence（CL） were proportional to the phenothiazines concentration without any sensitizers. So, a new flow-injection CL method has been developed. The optimum chemical conditions for the CL reaction were investigated. Results：Under the optimized conditions, the phenothiazines were determined. The linear range of the working curves were 1.0 × 10^-7 - 1.0 × 10^-5 g · mL^-1 for chlorpromazine hydrochloride and promethazine hydrochloride, 1.0 × 10^-7 - 1.0 × 10^-4 g · mL^-1 for perphenazine respectively;The detection limits of the method were 7.0 × 10^-8 g · mL^-1 ,5.0 × 10 ^-8 g·mL^-1and 2.0 × 10^-8 g · mL^-1 respectively. Conclusion：The method is simple, rapid, and sensitive, and it has been applied to the the determination of the phenothiazines in pharmaceutical injections and tablets with satisfactory

关 键 词：吩噻嗪类药物 流动注射化学发光法 测定 氯丙嗪 异丙嗪 奋乃静 

分 类 号：R971.4[医药卫生—药品] R927[医药卫生—药学]