利君沙有效成分琥乙红霉素的电位分析法测定  

Determination of Erythromycin Ethylsuccinate in Li-Jun-Sha Tablets by Potentiometry

作　　者：姚秉华[1] 陈金云[1] 白映平 杨国农[1] 

机构地区：[1]西安理工大学应用化学系,西安710048 [2]西安化工研究所,西安710048

出　　处：《药物分析杂志》2005年第12期1537-1539,共3页Chinese Journal of Pharmaceutical Analysis

基　　金：陕西省教育厅专项科研基金资助项目(No.02JK141)

摘　　要：目的:研制一种琥乙红霉素(EES)的聚氯乙烯(PVC)膜选择性电极,以用于利君沙有效成分的快速测定。方法:以琥乙红霉素与四苯硼钠形成的缔合物为电活性物质研制了琥乙红霉素 PVC 膜离子选择性电极,用于琥乙红霉素制剂的测定。结果:该电极的 Nernst 线性响应范围为2.8×10^(-5)～3.0×10^(-4)mol·L^(-1);斜率为44mV/pc;检测下限为1.00×10^(-5)mol·L^(-1);平均回收率达96.5%。结论:该电极制作方法简单,响应迅速,重现性较好,用于利君沙中有效成分琥乙红霉素的测定,其结果与电位滴定法、抗生素微生物检定法基本吻合。Objective：To establish a method for the determination of erythromycin ethylsuccinate （EES） in Li - Jun - Sha tablets by potentiometry. Method ： A new polyvingl chloride membrane selective electrode was prepared by using the mixture of erythromycin ethylsuccinate and sodium tetraphenylboron complex as active component. It has been used for the determination of EES in medieine. Results ： The eleetrode gave Nernst response to EES over the concentration range of 2. 8 × 10^-5 ～ 3.0 × 10^-4 mol · L^-1 with a slope of 44mV/p c. The detection limit was 1.00 × 10^-5mol · L^- 1, and the average recovery was up to 96. 5%. Conclusion：The preparation method of the electrode is simple. The results showed that the electrode has high reproductivity, stability and fast response. This method was used for the determination of EES in Li - Jun - Sha tablets with satisfactory.

关 键 词：琥乙红霉素 离子选择性电极 电位法 聚氯乙烯膜 利君沙 

分 类 号：R978.15[医药卫生—药品] R927[医药卫生—药学]