硬膜外注射脉络宁对脊神经根炎大鼠血清中白细胞介素-6的影响  

EFFECTS OF EPIDURAL INJECTION OF MAILUONING ON SERUM IL-6 LEVEL IN THE RATS WITH RADICULITIS

作　　者：支满霞[1] 高元朝[1] 夏淑君 陈力夯[3] 刘中良 

机构地区：[1]中国中医研究院望京医院,北京100102 [2]北京市放射免疫中心 [3]北京鼓楼中医院

出　　处：《中国疼痛医学杂志》2005年第6期343-345,共3页Chinese Journal of Pain Medicine

基　　金：首都医学发展科研基金资助课题

摘　　要：目的通过观察脊神经根炎大鼠血清中白细胞介素-6(IL-6)的含量,探讨硬膜外腔注射脉络宁治疗椎间盘源性腰腿痛的作用机制。方法选用Wistar雄性大鼠24只,随机分为四组正常组(Z),假手术组(K),脉络宁组(A)和模型组(S)。A组每只硬膜外腔注入脉络宁0.6ml/kg,每四天给一次药,一共给药四次;S组给予等量生理盐水。术后第18天从右心室取血2ml,检测各组大鼠血清中IL-6的含量。结果大鼠血清IL-6含量S组明显高于A组、Z组和K组,组间比较具有显著性差异(P<0.01),A组与Z组相比无显著性差异(P>0.05)。结论硬膜外腔注射脉络宁可降低脊神经根炎大鼠血清中IL-6含量,这可能是脉络宁治疗椎间盘源性腰腿痛的机制之一。Objective： To determine whether interleukin-6 （IL-6） is involved in nerve root pain induced by herniated lumbar disc, and to explore the clinical mechanism of Mailuoning. Methods ： 24 Wistar rats were randomly divided into four groups： normal group（ Z）, sham operation group （K）, model group （S） and Mailuoning therapy group（A）. The serum levels of IL-6 were measured 18 days after operation. Resuits： Serum IL-6 in Group A was very low; Groups S had the highest level of IL-6 among the four groups. IL-6 was decreased after epidural injection of Mailuoning and there was no significant difference between normal and Mailuoning groups （ P 〉 0.05 ）. Conclusion ： IL-6 may play a critical role in the development of nerve root pain. Mailuoning can decrease the serum level of IL-6.

关 键 词：硬膜外腔 脉络宁 白细胞介素-6 神经根炎 

分 类 号：R681.53[医药卫生—骨科学]