帕金森病的药物治疗  

Advance in Drug Treatment of Parkinson's Disease

作　　者：杨颖琳[1] 史美甫[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《中国药业》2005年第12期19-22,共4页China Pharmaceuticals

摘　　要：目的:介绍帕金森病近年来的药物治疗进展。方法:对帕金森病治疗药物的种类、用法、不良反应及各自的优缺点进行总结。结果:目前最有效的药物是左旋多巴/卡比多巴,此外尚有多巴胺激动剂(包括麦角胺类及非麦角胺类)、儿茶酚-O-甲基转移酶抑制剂、单胺氧化酶B抑制剂、抗胆碱能药物及其他药物等,所有药物均有一定的不良反应。结论:现有药物治疗仅可明显改善症状,延缓疾病发展,但均不能有效治愈帕金森病。Objective： Drug therapeutic advance in treatment of Parkinson＇s disease recently was reviewed. Methods： By collecting medical litrerature in recent years, every type of antlparkinsonians was analysed and compared in pharmacology, usage and adverse drug reaction. Results： Levadopa/carbidopa is the most effective symptomatic treatment for Parkinson＇s disease, other drugs include dopamine agonist which include ergot or non-ergot dopamine agonist, catechol-o- methyhransferase inhibitors, monoamine oxidase type B inhibits, anticholinergics and so on. Every drug has severe side effects. Conclusion： Drug therapy is effective for improving symptomatic treatment of Parkinson＇s disease, but can not root it.

关 键 词：帕金森病 左旋多巴 多巴胺激动剂 抗胆碱能药物 单胺氧化酶B抑制剂 

分 类 号：R971.5[医药卫生—药品]