α-玉米赤霉醇对实验性高脂血症兔的血脂代谢及血液流变学的影响  

Influence of α-Zearalanol on lipometabolism and hemorheology in experimental hyperlipidemia rabbits

作　　者：赵小元[1] 左萍萍[2] 段金虹[2] 陆媛[2] 张仪华[2] 程锦轩[2] 吴云清[2] 鲁杰[1] 孙仁宇[2] 戴顺龄[2] 

机构地区：[1]首都儿科研究所,北京市100020 [2]中国医学科学院,中国协和医科大学基础医学院,北京市100005

出　　处：《中国康复理论与实践》2005年第11期924-926,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金(38970342)

摘　　要：目的本研究是探讨α-玉米赤霉醇(-αZAL)在抗动脉粥样硬化(AS)作用中,对血脂代谢及血液流变学的影响。方法44只成熟未孕新西兰大耳白雌兔,分为5组,A组为正常对照组,B组为假手术组,C组为切除卵巢组,D组为切除卵巢并给予17β雌二醇(17βE2)阳性对照药组,E组为切除卵巢并给予-αZAL组。喂胆固醇(CHO)前与12周后,分别测定血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)含量。还分别测定了全血黏度、血浆黏度、红细胞聚集指数(AIRC)及纤维蛋白原及血小板聚集率。结果B、D、E组TC、TG、LDL-C明显低于C组(P<0.05);全血黏度、血浆黏度、AIRC和血小板聚集率也明显低于C组(P<0.05)。结论-αZAL可能通过干预血脂代谢,调节全血黏度、血浆黏度和AIRC及血小板聚集率,改善血管功能。Objective To investigate the effect of α-Zearalanol （α-ZAL） on lipometabolism and hemorheology in ovariectomized （OVX） hyperlipidemia rabbits. Methods 44 adult virgin female rabbits were divided into 5 groups, group A： normal control; group B： sham＋CHO; group C： OVX＋CHO; group D： OVX＋CHO＋17βE2 ; group E： OVX＋CHO＋α-ZAL. Cholesterol （CHO） was fed to rabbits for 12 weeks. Before and after feeding CHO, the serum lipid （TC,TG, LDL-C, HDL-C） were measured; Blood viscosity, plasma viscosity, aggregation index of RBC （AIRC） and fibrinogen were also assayed respectively. Results The serum levels of TC, TG and LDL-C in group B and E were significantly decreased compared with those in group C （P〈0.05） ; the level of blood viscosity, plasma viscosity and AIRC platelet aggregation rate in group D and E were also significantly decreased compared with those in group C （P〈0.05）. Conclusion α-ZAL can improve vascular function through the adjustment of lipometabolism and hemorheology.

关 键 词：植物雌激素 高脂血症 脂质代谢 血液流变学 Α-玉米赤霉醇 

分 类 号：R589.2[医药卫生—内分泌]