尿转化生长因子β_1对老年人早期糖尿病肾病的诊断意义  

Urinalysis of transforming growth factor-β_1 in old patients with diabetic nephropathy

作　　者：姚坚坚[1] 钱芸娟[1] 林琦[1] 李东风[1] 

机构地区：[1]广东省人民医院老年病研究所肾内科,广东广州市510080

出　　处：《中国康复理论与实践》2005年第11期940-941,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：广东省医学科学研究基金资助项目(A2001043)

摘　　要：目的探讨检测尿转化生长因子-β1(TGF-β1)对诊断老年人早期糖尿病肾病的临床价值。方法检测53例老年2型糖尿病患者及27名正常老年人的尿TGF-β1、尿微量白蛋白、尿α1-微球蛋白、β2-微球蛋白、空腹血糖及糖化血红蛋白并进行分析比较。结果正常白蛋白尿DM组尿TGF-β1为(21.2±7.32)ng/mmolCr,微量白蛋白尿DM组尿TGF-β1为(58.79±25.93)ng/mmolCr,两组间有非常显著性差异(P<0.01),均明显高于正常老年对照组的(7.79±3.58)ng/mmolCr(均P<0.01)。相关分析表明,尿TGF-β1与尿微量白蛋白(r=0.5415)、尿α1-微球蛋白(r=0.6282)、尿β2-微球蛋白(r=0.3248)呈显著正相关(均P<0.01),与糖化血红蛋白无相关性(r=0.2304,P>0.05)。结论尿TGF-β1测定似可作为老年2型糖尿病肾病早期诊断的一项敏感可靠的指标。Objective To search detecting urine transforming growth factor-β1 （TGF-β1） of type 2 diabetes mellitus （DM） in diagnosing early diabetic nephropathy in old patients. Methods TGF-β1, microalbumin,microglobulin α1 and microglobulin 132 in urine from 53 cases of old type 2 diabetics and 27 cases of normal controls were detected. Results TGF-β1 was （21.2±7.32） ng/mmolCr in diabetics whose urine albumin were normal and was （58.79±25.93） ng/mrnolCr in diabetics whose urine microalbumin was abnormal（P〈0. β1）. Both were significantly higher than that of the normal control which was （7.79±3.58） ng/mmolCr （P〈0.01）. TGF-β1 was direct remarkably correlative with microablumin （r=0. 5415）, microglobulin α1 （r = 0. 6282） and microglobulin 132 （r= 0. 3248） （P〈0.01 respectively）, but was nothing with glycohemoglobin （r= 0. 2304, P〉0.05）. Conclusion TGF-β1 detection may be used as a sensitive and reliable guideline to diagnose early diabetic nephropathy in old diabetics.

关 键 词：糖尿病 并发症 糖尿病肾病 转化生长因子-Β1 

分 类 号：R587.2[医药卫生—内分泌]