旋光法测定注射用盐酸阿糖胞苷的含量  

POLARIMETRIC DETERMINATION OF CYTARABINE HYDROCHLORIDE IN ITS INJECTIONS

作　　者：黄锁义[1] 张中海[2] 文辉忠[3] 

机构地区：[1]广西右江民族医学院化学教研室,百色533000 [2]华东师范大学化学系,上海200062 [3]广西大学化学化工学院,南宁530004

出　　处：《理化检验（化学分册）》2005年第12期910-911,共2页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：国家教育部高等学校访问学者基金资助项目

摘　　要：对注射用盐酸阿糖胞苷采用旋光法进行测定,测定管长为1 cm.当盐酸阿糖胞苷浓度在1～9.000 0 g·L-1之间时,旋光度与浓度呈线性关系,回归方程为a=0.130 1 C+0.000 1,相关系数为0.999 9,平均回收率为99.93%,RSD为0.47%.方法简便、快速、准确,适合于药厂、医院对产品及制剂的快速分析.Polarimetry was applied to the determination of content of cytarabinehydrochloride in injections. Degree of optical rotation of the drug was determined with polarized light of 589.3 nm passing through a measuring tube with 1 cm in light path. Experimental results showed that linear relationship between the measured signal and concentration of cytarabine hydrochloride was kept in the range from 1 to 9. 000 0 g · L^-1, with the following linear regression equation： α=0. 130 1 C＋0. 000 1 （r=0. 999 9）, Results of recovery test gave an average recovery of 99. 93% and a RSD （n= 6） of 0.47%, In its application to the analysis of injection samples of different hatches, results obtained by this method were in conformity with these obtained by the pharmacopoeia method of UVspectrometry.

关 键 词：旋光法 注射用盐酸阿糖胞苷 测定 

分 类 号：O621.22[理学—有机化学]