二茂铁甲基季铵盐对异烟肼的电催化氧化及其电分析方法研究  

Study on electrocatalytic oxidation of isoniazid by(FcM)TMA and its application in the content determination by square wave voltammetry

作　　者：姚慧琴[1] 韩晓霞[1] 高作宁[1] 张娟[1] 梁斌[1] 

机构地区：[1]宁夏大学化学化工学院宁夏能源化工重点实验室,银川750021

出　　处：《分析试验室》2005年第12期29-33,共5页Chinese Journal of Analysis Laboratory

基　　金：教育部科学研究重点项目(204149);宁夏自然科学基金(E1001)资助

摘　　要：研究了铂电极上二茂铁甲基季铵盐电催化氧化异烟肼的电化学行为,并且对异烟肼药物的电分析方法进行了研究.实验结果发现,二茂铁甲基季铵盐对异烟肼的电化学氧化具有很好的催化作用.当二茂铁甲基季铵盐浓度一定时,催化氧化峰电流与异烟肼浓度在5×10-5～6×10-4mol/L的浓度范围有良好的线性关系(r=0.9984),运用方波伏安法测定了异烟肼样品含量,与紫外分光光度法所得结果进行比较,相对标准偏差在0.5%以内,标准加入的回收率在98.0%～101.0%之间.The electrocatalytic oxidation behaviors of iso- niazid by （Ferrocenylmethyl）trimethylammonium at a platinum electrode have been studied. The electrochemical experimental results show that the response could be greatly enhanced by using （FcM）TMA. At the constant concentration of （FcM）TMA, The catalytic peak current was proportional to the concentration of INH over the range of 5×10^-5～6×10^-4mol/L with a correlation coefficient of 0. 9984. INH in pharmaceutical products was determined by SWV method. The accuracy of the SWV method was also checked by UV spectrophotometry. Compared with the UV method, the relative standard deviation is below 0.5 % and recovery is in the range of 98.0% - 101.0%. The results are satisfactory.

关 键 词：二茂铁甲基季铵盐 异烟肼 电催化氧化 电分析方法 

分 类 号：O657.1[理学—分析化学]