Antimicrobial Properties and Toxicity of Anthraquinones by Microcalorimetric Bioassay  

作　　者：武彦文 欧阳杰 肖小河 高文远 刘义 

机构地区：[1]Instttute of Chmese Medtcine, 302 Hospital of People's Liberation Army, Beijing 100039, China [2]Tianjin Key Laboratory of Food Nutrition and Safety, Faculty of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300222, China [3]Department of Food Science and Engineering, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China [4]College of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China [5]Department of Chemistry, College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, China

出　　处：《Chinese Journal of Chemistry》2006年第1期45-50,共6页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 39970911 and 30371724）.

摘　　要：The growth therrnogenic curves of Staphylococcus aureus and Tetrahymena thermophila affected by 1,8-dihydroxyanthraquinone, emodin and rhein were determined quantitatively by microcalorimetry. The inhibitory effects of the three anthraquinones （AQ） on S. aureus revealed that the sequence of antimicrobial activity of those was rhein〉emodin〉 1,8-dihydroxyanthraquinone. The toxicity of the three AQ on T. thermophila indicated that all the tested AQ were toxic to the tested protozoa and the hydroxyl and carboxyl substituted at different position of anthraquinone ring resulted in the enhancement of toxicity.The growth therrnogenic curves of Staphylococcus aureus and Tetrahymena thermophila affected by 1,8-dihydroxyanthraquinone, emodin and rhein were determined quantitatively by microcalorimetry. The inhibitory effects of the three anthraquinones （AQ） on S. aureus revealed that the sequence of antimicrobial activity of those was rhein〉emodin〉 1,8-dihydroxyanthraquinone. The toxicity of the three AQ on T. thermophila indicated that all the tested AQ were toxic to the tested protozoa and the hydroxyl and carboxyl substituted at different position of anthraquinone ring resulted in the enhancement of toxicity.

关 键 词：ANTHRAQUINONE MICROCALORIMETRY Staphylococcus aureus Tetrahymena thermophila inhibitory effect 

分 类 号：O625.154[理学—有机化学]