A Rapid and Convenient Synthetic Route to Novel 1,5-Benzodiazepine Derivatives of 5-Methyl-3-phenyl-2-oxo-△^4-1,3,4-oxadiazolines from ρ-Acetylphenylsydnone and Their Pharmacological Activity  

作　　者：KAMBLE,Ravindra R. SUDHA, Belagur S. 

机构地区：[1]Department of Chemistry and Food Science, Yuvaraja's College, University of Mysore, Mysore-570 005, India

出　　处：《Chinese Journal of Chemistry》2006年第1期79-84,共6页中国化学（英文版）

摘　　要：A simple and high yielding method for the integration of 1,5-benzodiazepines integrated with 5-methyl- 2-oxo-3-phenyl-△^4-1,3,4-oxadiazolines in 75%-90% yield by microwave irradiation is devised. Microwave-accelerated reaction was compared with thermal method. All the compounds were characterized by physical, analytical and spectral （IR, 1^H NMR, MS） data. Title compounds were screened for preliminary pharmacological activities.A simple and high yielding method for the integration of 1,5-benzodiazepines integrated with 5-methyl- 2-oxo-3-phenyl-△^4-1,3,4-oxadiazolines in 75%-90% yield by microwave irradiation is devised. Microwave-accelerated reaction was compared with thermal method. All the compounds were characterized by physical, analytical and spectral （IR, 1^H NMR, MS） data. Title compounds were screened for preliminary pharmacological activities.

关 键 词：ρ-acetylphenylsydnone 1 3-dipolar cycloaddition 1 5-diazepine Michael addition microwave irradiation thermal method 

分 类 号：O626.26[理学—有机化学]