芦丁镇痛作用部位和机制的研究  

Central analgesic activity and possible mechanism of rutin

作　　者：宋必卫[1] 田薇[1] 陈志武[1] 马传庚[1] 刘颖雪 岑德意[1] 

机构地区：[1]安徽医科大学药理教研室,安徽医科大学第一附属医院口腔科,阜阳地区医院药剂科

出　　处：《安徽医科大学学报》1996年第1期1-3,共3页Acta Universitatis Medicinalis Anhui

摘　　要：在小鼠扭体模型上，ｉｃｖ芦丁０．３１～１．３０ｍｇ·ｋｇ－１或ｉｐ芦丁６．２５～２５．００ｍｇ·ｋｇ－１均呈剂量依赖性镇痛作用，中枢给药所需剂量为外周用药的１／２０。ｉｃｖＣａＣｌ２或乙二胺四乙酸能拮抗或增强ｉｐ芦丁的镇痛作用。将小剂量芦丁敷于复发性口疮病人的溃疡面上不产生明显镇痛效果。上述结果表明芦丁镇痛部位主要是中枢而不是外周。The present work was designed to investigate the analgesic site and possible mechanism of rutin. Rutin, either 0. 31～1. 30 mg · kg-1 icv or 6. 25￣25. 00 mg · kg-1 ip,dose-dependently inhibited the writhing response in mice, and icv CaCl2 or EDTA antagonized or enhanced the analgesia of rutin. It was also observed that rutin did not relieve the oral pain when applied to human oral ulcer surface in small dose. The results suggest that rutin has central analgesic activity and its mechanism might be due to calcium antagonism.

关 键 词：芦丁 药理学 止痛药 

分 类 号：R971.1[医药卫生—药品]