乙型慢性肝炎和乙肝肝硬化患者血清IGF-1水平的临床研究  

Detection of Serum Free Insulin-Iike Growth Factor 1 in Patients with Chronic Hepatitis B and Liver Cirrhosis

作　　者：刘惠敏[1] 张导文[1] 刘宏景[1] 娄国强[1] 金巧菲[1] 赵立夫[1] 张曼[1] 

机构地区：[1]浙江省杭州市第六人民医院,310014

出　　处：《医学研究通讯》2005年第11期23-25,共3页Bulletin of Medical Research

摘　　要：目的检测慢性乙型肝炎、慢性重性肝炎和乙肝肝硬化患者血清游离胰岛素样生长因子1(IGF-1)的水平,分析探讨ICF-1与患者病情和预后的关系。方法受检对象包括慢性轻度、中度、重度肝炎各30例,肝硬化30例,慢性重型肝炎30例以及正常对照20例,应用ELISA方法检测其血清游离IGF-1水平,并进行统计学分析。结果慢性肝炎轻度、中度、重度患者的血清游离IGF-1水平分别为222.77±49.61ng/ml、206.27±56.33ng/ml和176.37±76.07ng/ml,乙肝肝硬化和慢性重型肝炎患者分别为106.58±72.77ng/nd和114.99±70.21ng/ml,对照组为251.05±41.53ng/ml,各实验组血清游离IGF-1水平均明显低于对照组,乙肝肝硬化组及重型肝炎组血清游离IGF-1水平均明显低于慢乙肝轻、中、重度组。结论血清IGF-1检测可用于评估肝硬化和慢性重型肝炎患者的病情和预后;IGF-1与慢性乙型肝炎的病理生理学过程有关。Objective To evaluate the serum free insulin - like growth factor 1 （IGF - 1） level and its correlation with the severity and prognosis in patients with chronic hepatitis B, liver cirrhosis and severe chronic hepatitis. Methods Serum free IGF - 1 was detected by ELISA in 30 patients with chronic mild hepatitis, 30 patients with chronic moderate hepatitis, 30 patients with chronic severe hepatitis, 30 with liver cirrhosis and 30 with severe chronic hepatitis. 20 normal ones for negative control. Results Serum free IGF - 1 was 222.77±49.61ng/ml in patients with chronic mild hepatitis; 206.27±56.33ng/ml in chronic moderate hepatitis; 176.37±76.07ng/ml in chronic severe hepatitis; 106.58±72.77ng/ml in liver cirrhosis; 114.99±70.21ng/ml in severe chronic hepatitis and 251.05±41.53ng/ml in control group. In all the test group, the serum free IGF - 1 levels were significantly lower than that of the control group. The serum free IGF - 1 levels in liver cirrhosis and severe chronic hepatitis group were significantly lower than that of chronic hepatitis group. Conclusions It is useful to test serum free IGF - 1 for evaluating the severity and prognosis of patients with liver cirrhosis and severe chronic hepatitis. There may be some correlation between IGF - 1 and the pathophysiological process in chronic hepatitis B.

关 键 词：慢性肝炎 肝硬化 胰岛素样生长因子-1 

分 类 号：R587.1[医药卫生—内分泌] R512.62[医药卫生—内科学]