马沙拉嗪的合成工艺改进  

Improved Process of the Synthesis of Mesalazine

作　　者：王勤[1] 

机构地区：[1]中国石油大学化学化工学院,山东东营257061

出　　处：《浙江化工》2005年第12期13-14,共2页Zhejiang Chemical Industry

摘　　要：水杨酸在固体酸的催化下,被硝酸选择性硝化,合成5-硝基水杨酸,再经催化加氢合成马沙拉嗪,总产率接近80%,纯度达到99.0%以上。并且工艺条件易于控制,污染少,具有良好的工业应用前景。5-nitro-salicylic-acid was synthesied by the alternative nitration of nitric acid. Mesalazine was formed by catalysis hydrogenation. The gross output rate was close to 80% and the purity of product was over 99.0%. The process condition was easy to control, but there was little pollution. That had a good prospect of industrical application.

关 键 词：马沙拉嗪 固体酸 硝化 加氢 

分 类 号：TQ463.53[化学工程—制药化工]