多种方法联合检测对胸腔积液的鉴别诊断  

The differential diagnosis of pleural effusion by multiple methods combination

作　　者：惠雅琳[1] 赵文瑛[1] 刘惠珍[1] 

机构地区：[1]武警工程学院医院内科,西安710086

出　　处：《陕西医学杂志》2006年第1期37-39,共3页Shaanxi Medical Journal

摘　　要：目的:探讨胸腔积液及血清中癌胚抗原(CEA)、细胞角蛋白片段抗原21-1(CYFRA 21-1)及胸腔积液脱落细胞学、免疫荧光法检测肿瘤细胞在良恶性胸腔积液鉴别诊断中的价值。方法:测定30例结核性和32例癌性胸腔积液患者胸腔积液及血清中CEA、CYFRA 21-1含量,并行胸腔积液脱落细胞学、免疫荧光法检测肿瘤细胞检查。结果:CEA、CYFRA 21-1对胸腔积液诊断的敏感性及特异性分别为81%、56%和64%、95%,联合检测胸水脱落细胞、免疫荧光法检测肿瘤细胞,其特异性和敏感性均提高到100%。结论:多种方法联合检测具有互补作用,能提高诊断准确率。Objective. To explore the value of measurement of CEA , CYFRA21-1 in serum and pleural fluid combined with the exfoliative cytology examination of pieural effusion, immunofluorescence technique in differential diagnosis of benign and malignant pleural effusion. Methods The CEA and CYFRA21-1 levels of 30 patients with tuberculosis and 32 patients with cancers in serum and pleural fluids were measured, and synchronously the exfoliative cytology examination of pleural effusion and immunofluorescence technique were used to measure the tumor cells. Results; The sensitivity and specificity of CEA and CYFRA21-1 in differential diagnosis of pleural effusion were 81%, 56%, and 64%, 95% respectively, in combination with the exfoliative cytology examination of pleural effusion and immunofluorescence technique, the sensitivity and sepcificity were increased to 100%. Conclusion： The combination of multiple methods has supplementary effects, and can increase the diagnostic accuracy significantly.

关 键 词：胸腔积液/诊断 癌胚抗原 角蛋白 荧光免疫测定 

分 类 号：R561.3[医药卫生—呼吸系统] R734.2[医药卫生—内科学]