泰妥拉唑的合成  

Synthesis of Tenatoprazole

作　　者：鲍亚杰[1] 苏冰[2] 李晓东[1] 王雅丽[1] 苏焕臣 

机构地区：[1]吉林省药物研究所,吉林长春130062 [2]白求恩医科大学制药厂,吉林长春130012

出　　处：《中国医药工业杂志》2006年第1期3-4,共2页Chinese Journal of Pharmaceuticals

摘　　要：2,3-二氨基-6-甲氧基吡啶和乙氧基荒酸钾经闭环得到5-甲氧基-1H-咪唑并[4,5-b]吡啶-2-硫醇,再与2-氯甲基-3,5-二甲基-4-甲氧基吡啶缩合后氧化得到抗溃疡药泰妥拉唑,总收率48%。Tenatoprazole was synthesized from 2,3-diamino-6-methoxypyridine by cyclization with potassium xanthogenate to give 5-methoxy- 1H-imidazo [4,5-b] pyridine-2-thiol which subjected to condensation with 2-chloromethyl- 3,5-dimethyl-4-methoxypyridine followed by oxidation with an overall yield of 48 %.

关 键 词：泰妥拉唑 H^+/K^+-ATP酶抑制剂 抗溃疡药 合成 

分 类 号：R975.6[医药卫生—药品]